Journal
JOURNAL OF COMPUTATIONAL CHEMISTRY
Volume 42, Issue 20, Pages 1452-1460Publisher
WILEY
DOI: 10.1002/jcc.26551
Keywords
alternatives to animal testing; in silico predictions; QSAR; QSARINS; virtual screening
Categories
Funding
- European Chemical Industry Council [CEFIC-LRI ECO44]
- PhD Course in Chemical and Environmental Sciences (DISCA -University of Insubria)
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The new software QSARINS-Chem standalone version is a multiplatform tool for the in silico profiling of organic chemicals. Based on the concept of QSARINS-chem module embedded in the QSARINS software, it predicts biotransformation rates and aquatic toxicities, and offers tools for analysis. Additionally, a comprehensive and transparent database of molecular structures is provided.
The new software QSARINS-Chem standalone version is a multiplatform tool, freely downloadable, for the in silico profiling of multiple properties and activities of organic chemicals. This software, which is based on the concept of the QSARINS-chem module embedded in the QSARINS software, has been fully redesigned and redeveloped in the Java (TM) language. In addition to a selection of models included in the old module, the new software predicts biotransformation rates and aquatic toxicities of pharmaceuticals and personal care products in multiple organisms, and offers a suite of tools for the analysis of predictions. Furthermore, a comprehensive and transparent database of molecular structures is provided. The new QSARINS-Chem standalone version is an informative and solid tool, which is useful to support the assessment of the potential hazard and risks related to organic chemicals and is dedicated to users which are interested in the application of QSARs to generate reliable predictions.
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