4.4 Article

Fabrication of Gallic Acid Loaded SeNPs and their Neuroprotection Effect for Treatment of Ischemic Stroke

Journal

JOURNAL OF CLUSTER SCIENCE
Volume 33, Issue 4, Pages 1427-1433

Publisher

SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10876-021-02070-z

Keywords

Selenium nanoparticles; CIRI; Gallic acid

Ask authors/readers for more resources

This study developed a delivery system of selenium nanoparticles loaded with gallic acid (GA-SeNPs) for the treatment of cerebral ischemia-reperfusion injury, showing potential efficacy in vitro experiments.
Ischemic stroke (IS) is a usual cerebrovascular ailment having high mortality and morbidity globally. The approaches for the treatment and prevention of cerebral ischemia-reperfusion injury (CIRI) are very limited. In this study, a delivery system of selenium nanoparticles loaded with gallic acid (GA-SeNPs) was developed utilizing ascorbic acid (AA) as a reducing agent and gallic acid (GA) as a capping agent. In pharmacokinetic study, GA-SeNPs clearly increases the AUC of the plasma concentration-time and extended GA half-life. In vitro effects of GA-SeNPs in the middle cerebral artery occlusion (MCAO) model and the oxygen glucose deprivation (OGD) model was measured. Finally, GA-SeNPs can be utilized as an efficient vehicle for delivery of GA in CIRI treatment.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.4
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available