Journal
JOURNAL OF CLINICAL EPIDEMIOLOGY
Volume 132, Issue -, Pages 26-33Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jclinepi.2020.11.026
Keywords
HIV; Manitoba; Cohort studies; Epidemiology; Retention in care; Patient care
Funding
- Canadian Institutes of Health Research [CIHR] [TT5-128270]
- CIHR Canada Graduate Scholarship Doctoral Award
- University of Manitoba's Sir Gordon Wu Scholarship
- Canadian Association for HIV Research's Dr. Robert Remis Academic Scholarship
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The first HIV care cascade for Manitoba, Canada was developed in 2013, with 74.4% of diagnosed cohort participants being virologically suppressed in 2017. There was a leakage of 9.3% between the first and second steps of the cascade.
Background and Objective: We describe the development of the first HIV care cascade for Manitoba, Canada, detailing steps taken to establish indicator definitions for each cascade step, and derive a full complement of local estimates. Methods: Manitoba is a Canadian Prairie Province with disproportionately high annual HIV incidence. In 2013, a clinical cohort of people living with HIV was established within the primary HIV care program in Manitoba. Using cohort data from 2017, we describe the creation of a set of indicator definitions and calculate estimates for each cascade step to create the first Manitoban cascade model. Results: Of the 703 cohort participants categorized as alive and diagnosed, 638 (90.8%) were in care, 606 (86.2%) retained in care, 573 (81.5%) on treatment, and 523 (74.4%) virologically suppressed. The greatest point of leakage occurred between the first and second steps; 9.3% of those alive and diagnosed in 2017 were not in care in the same calendar year. Conclusion: This is the first comprehensive examination of HIV clinical epidemiology in Manitoba using a cascade framework, with the potential inform programming to improve service coverage within Manitoba and significantly contribute to evidence informing provincial policies to support these efforts. ? 2020 Elsevier Inc. All rights reserved.
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