Comment on The Gibbs free energy of cavity formation in a diverse set of solvents[J. Chem. Phys. 153, 134501 (2020)]

It is pointed out that the unexpected result that the magnitude of the reversible work of cavity creation in ethylene glycol proves to be larger than that in water [I. Sedov and T. Magsumov, J. Chem. Phys. 153, 134501 (2020)] could be due to that (a) the density of the used computational model of this liquid is significantly larger than the experimental one and (b) the procedure adopted to perform the comparison among the different liquids is not strictly correct. It is also indicated that several lines of evidence suggest that the magnitude of the reversible work of cavity creation in water can be larger than that in ethylene glycol.

Automated summary

The larger magnitude of reversible work of cavity creation in ethylene glycol compared to water could be attributed to the significantly larger density of the computational model used and the incorrect procedure adopted for comparison. However, there is evidence suggesting that the magnitude of reversible work of cavity creation in water may actually be larger.