Journal
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
Volume 25, Issue 9, Pages 4173-4182Publisher
WILEY
DOI: 10.1111/jcmm.16490
Keywords
14‐ 3‐ 3 proteins; biological function; innate immunity; viral infection
Categories
Funding
- National Natural Science Foundation of China [31772708]
- National key special project Technology boosts economy 2020 [SQ2020YFF0426570]
Ask authors/readers for more resources
14-3-3 proteins are highly conserved across species and regulate multiple signaling pathways by interacting with proteins containing phosphorylated 14-3-3-binding motifs. Research has shown their involvement in protein trafficking, cell-cycle control, apoptosis, autophagy, and other cell signal transduction pathways, as well as their role in viral infections and innate immunity.
14-3-3 proteins are highly conserved in species ranging from yeast to mammals and regulate numerous signalling pathways via direct interactions with proteins carrying phosphorylated 14-3-3-binding motifs. Recent studies have shown that 14-3-3 proteins can also play a role in viral infections. This review summarizes the biological functions of 14-3-3 proteins in protein trafficking, cell-cycle control, apoptosis, autophagy and other cell signal transduction pathways, as well as the associated mechanisms. Recent findings regarding the role of 14-3-3 proteins in viral infection and innate immunity are also reviewed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available