The role of 14-3-3 proteins in cell signalling pathways and virus infection

14-3-3 proteins are highly conserved in species ranging from yeast to mammals and regulate numerous signalling pathways via direct interactions with proteins carrying phosphorylated 14-3-3-binding motifs. Recent studies have shown that 14-3-3 proteins can also play a role in viral infections. This review summarizes the biological functions of 14-3-3 proteins in protein trafficking, cell-cycle control, apoptosis, autophagy and other cell signal transduction pathways, as well as the associated mechanisms. Recent findings regarding the role of 14-3-3 proteins in viral infection and innate immunity are also reviewed.

Automated summary

14-3-3 proteins are highly conserved across species and regulate multiple signaling pathways by interacting with proteins containing phosphorylated 14-3-3-binding motifs. Research has shown their involvement in protein trafficking, cell-cycle control, apoptosis, autophagy, and other cell signal transduction pathways, as well as their role in viral infections and innate immunity.