Journal
JOURNAL OF BIOSCIENCE AND BIOENGINEERING
Volume 132, Issue 1, Pages 81-87Publisher
SOC BIOSCIENCE BIOENGINEERING JAPAN
DOI: 10.1016/j.jbiosc.2021.03.008
Keywords
Cryogel; Chitosan; Hydrophobic modification; Biomedical material; Drug carrier
Funding
- Japan Society for the Promotion of Science (JSPS) [18K04815]
- Grants-in-Aid for Scientific Research [18K04815] Funding Source: KAKEN
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This study reports the successful fabrication of hydrophobically modified chitosan cryogel, which can be optimized for strength, adsorption, and release of hydrophobic dye by varying alkyl chain length and substitution degree. The cryogel shows potential as a biomedical material.
This research reports the success of the fabrication of hydrophobically modified chitosan cryogel. Chitosan was modified with alkyl groups through reductive animation. By varying the alkyl chain length and the substitution degree, the resulting cryogel could be optimized for strength, and the adsorption and release of hydrophobic dye, a model for hydrophobic medicines. By optimizing these attributes, the hydrogel was found to have the potential as a biomedical material. (C) 2021, The Society for Biotechnology, Japan. All rights reserved.
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