Related references
Note: Only part of the references are listed.Reduction of Squalene Epoxidase by Cholesterol Accumulation Accelerates Colorectal Cancer Progression and Metastasis
Soo Young Jun et al.
GASTROENTEROLOGY (2021)
A key mammalian cholesterol synthesis enzyme, squalene monooxygenase, is allosterically stabilized by its substrate
Hiromasa Yoshioka et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)
Squalene and cholesterol in the balance at the ER membrane
James A. Nathan
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)
Doa10 is a membrane protein retrotranslocase in ER-associated protein degradation
Claudia C. Schmidt et al.
ELIFE (2020)
Preclinical toxicology profile of squalene epoxidase inhibitors
Raj Nagaraja et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2020)
Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death
Javier Garcia-Bermudez et al.
NATURE (2019)
Impaired plasmalogen synthesis dysregulates liver X receptor-dependent transcription in cerebellum
Masanori Honsho et al.
JOURNAL OF BIOCHEMISTRY (2019)
Non-canonical ubiquitination of the cholesterol-regulated degron of squalene monooxygenase
Ngee Kiat Chua et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2019)
Valosin-containing protein mediates the ERAD of squalene monooxygenase and its cholesterol-responsive degron
Ngee Kiat Chua et al.
BIOCHEMICAL JOURNAL (2019)
Structure and inhibition mechanism of the catalytic domain of human squalene epoxidase
Anil K. Padyana et al.
NATURE COMMUNICATIONS (2019)
A chemical biology screen identifies a vulnerability of neuroendocrine cancer cells to SQLE inhibition
Christopher E. Mahoney et al.
NATURE COMMUNICATIONS (2019)
Partial proteasomal degradation of Lola triggers the male-to-female switch of a dimorphic courtship circuit
Kosei Sato et al.
NATURE COMMUNICATIONS (2019)
A Proximity Labeling Strategy Provides Insights into the Composition and Dynamics of Lipid Droplet Proteomes
Kirill Bersuker et al.
DEVELOPMENTAL CELL (2018)
A VCP inhibitor substrate trapping approach (VISTA) enables proteomic profiling of endogenous ERAD substrates
Edmond Y. Huang et al.
MOLECULAR BIOLOGY OF THE CELL (2018)
IUPred2A: context-dependent prediction of protein disorder as a function of redox state and protein binding
Balint Meszaros et al.
NUCLEIC ACIDS RESEARCH (2018)
The cancer-associated microprotein CASIMO1 controls cell proliferation and interacts with squalene epoxidase modulating lipid droplet formation
Maria Polycarpou-Schwarz et al.
ONCOGENE (2018)
Squalene epoxidase drives NAFLD-induced hepatocellular carcinoma and is a pharmaceutical target
Dabin Liu et al.
SCIENCE TRANSLATIONAL MEDICINE (2018)
Proteomic analysis of monolayer-integrated proteins on lipid droplets identifies amphipathic interfacial alpha-helical membrane anchors
Camille I. Pataki et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
Shavenbaby and Yorkie mediate Hippo signaling to protect adult stem cells from apoptosis
Jerome Bohere et al.
NATURE COMMUNICATIONS (2018)
Improving protein disorder prediction by deep bidirectional long short-term memory recurrent neural networks
Jack Hanson et al.
BIOINFORMATICS (2017)
UniProt: the universal protein knowledgebase
Alex Bateman et al.
NUCLEIC ACIDS RESEARCH (2017)
A conserved degron containing an amphipathic helix regulates the cholesterol-mediated turnover of human squalene monooxygenase, a rate-limiting enzyme in cholesterol synthesis
Ngee Kiat Chua et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2017)
fLPS: Fast discovery of compositional biases for the protein universe
Paul M. Harrison
BMC BIOINFORMATICS (2017)
Cholesterol uptake and regulation in high-grade and lethal prostate cancers
Konrad H. Stopsack et al.
CARCINOGENESIS (2017)
Squalene is lipotoxic to yeast cells defective in lipid droplet biogenesis
Martin Valachovic et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2016)
AUCpreD: proteome-level protein disorder prediction by AUC-maximized deep convolutional neural fields
Sheng Wang et al.
BIOINFORMATICS (2016)
Cholesterol Metabolism and Prostate Cancer Lethality
Konrad H. Stopsack et al.
CANCER RESEARCH (2016)
Cholesterol homeostasis: How do cells sense sterol excess?
Vicky Howe et al.
CHEMISTRY AND PHYSICS OF LIPIDS (2016)
Endoplasmic Reticulum-associated Degradation of Pcal p, a Polytopic Protein, via Interaction with the Proteasome at the Membrane
Nathan Smith et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2016)
Substrate Ubiquitination Controls the Unfolding Ability of the Proteasome
Eden L. Reichard et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2016)
An atomic structure of the human 26S proteasome
Xiuliang Huang et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2016)
An atomic structure of the human 26S proteasome
Xiuliang Huang et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2016)
Squalene epoxidase is a bona fide oncogene by amplification with clinical relevance in breast cancer
David N. Brown et al.
SCIENTIFIC REPORTS (2016)
The Regulatory Domain of Squalene Monooxygenase Contains a Re-entrant Loop and Senses Cholesterol via a Conformational Change
Vicky Howe et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
Inntags: small self-structured epitopes for innocuous protein tagging
Maya V. Georgieva et al.
NATURE METHODS (2015)
Intrinsically disordered proteins in cellular signalling and regulation
Peter E. Wright et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2015)
Pri sORF peptides induce selective proteasome-mediated protein processing
J. Zanet et al.
SCIENCE (2015)
DISOPRED3: precise disordered region predictions with annotated protein-binding activity
David T. Jones et al.
BIOINFORMATICS (2015)
PhosphoSitePlus, 2014: mutations, PTMs and recalibrations
Peter V. Hornbeck et al.
NUCLEIC ACIDS RESEARCH (2015)
Squalene mono-oxygenase, a key enzyme in cholesterol synthesis, is stabilized by unsaturated fatty acids
Julian Stevenson et al.
BIOCHEMICAL JOURNAL (2014)
DHCR24 associates strongly with the endoplasmic reticulum beyond predicted membrane domains: implications for the activities of this multi-functional enzyme
Eser J. Zerenturk et al.
BIOSCIENCE REPORTS (2014)
Slipping Up: Partial Substrate Degradation by ATP-dependent Proteases
Nicholas D. Nassif et al.
IUBMB LIFE (2014)
Sequential Actions of the AAA-ATPase Valosin-containing Protein (VCP)/p97 and the Proteasome 19 S Regulatory Particle in Sterol-accelerated, Endoplasmic Reticulum (ER)associated Degradation of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase
Lindsey L. Morris et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
The E3 Ubiquitin Ligase MARCH6 Degrades Squalene Monooxygenase and Affects 3-Hydroxy-3-Methyl-Glutaryl Coenzyme A Reductase and the Cholesterol Synthesis Pathway
Noam Zelcer et al.
MOLECULAR AND CELLULAR BIOLOGY (2014)
Proteasome-Mediated Processing of Def1, a Critical Step in the Cellular Response to Transcription Stress
Marcus D. Wilson et al.
CELL (2013)
A Practical Comparison of Ligation-Independent Cloning Techniques
Julian Stevenson et al.
PLOS ONE (2013)
Squalene monooxygenase – a target for hypercholesterolemic therapy
Agnieszka Belter et al.
BIOLOGICAL CHEMISTRY (2011)
Overlap extension PCR cloning: a simple and reliable way to create recombinant plasmids
Anton V. Bryksin et al.
BIOTECHNIQUES (2010)
The Otubain YOD1 Is a Deubiquitinating Enzyme that Associates with p97 to Facilitate Protein Dislocation from the ER
Robert Ernst et al.
MOLECULAR CELL (2009)
Analyzing real-time PCR data by the comparative C-T method
Thomas D. Schmittgen et al.
NATURE PROTOCOLS (2008)
Cellular cholesterol trafficking and compartmentalization
Elina Ikonen
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)
Endogenous 24(S),25-epoxycholesterol fine-tunes acute control of cellular cholesterol homeostasis
Jenny Wong et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
PrDOS: prediction of disordered protein regions from amino acid sequence
Takashi Ishida et al.
NUCLEIC ACIDS RESEARCH (2007)
A novel protein-processing domain in Gli2 and Gli3 differentially blocks complete protein degradation by the proteasome
Yong Pan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Harnessing homologous recombination in vitro to generate recombinant DNA via SLIC
Mamie Z. Li et al.
NATURE METHODS (2007)
Characterization of the proteasome interaction with the Sec61 channel in the endoplasmic reticulum
Waiyan Ng et al.
JOURNAL OF CELL SCIENCE (2007)
Proteasome-mediated protein processing by bidirectional degradation initiated from an internal site
Wojciech Piwko et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2006)
Selective identification of newly synthesized proteins in mammalian cells using bioorthogonal noncanonical amino acid tagging (BONCAT)
Daniela C. Dieterich et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Length-dependent prediction of protein intrinsic disorder
Kang Peng et al.
BMC BIOINFORMATICS (2006)
A conserved processing mechanism regulates the activity of transcription factors Cubitus interruptus and NF-κB
L Tian et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2005)
Membrane topology of human Insig-1, a protein regulator of lipid synthesis
JD Feramisco et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
An unstructured initiation site is required for efficient proteasome-mediated degradation
S Prakash et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2004)
Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes
JD Horton et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
A cryptic protease couples deubiquitination and degradation by the proteasome
TT Yao et al.
NATURE (2002)
Mobilization of processed, membrane-tethered SPT23 transcription factor by CDC48UFD1/NPL4, a ubiquitin-selective chaperone
M Rape et al.
CELL (2001)
CAST: an iterative algorithm for the complexity analysis of sequence tracts
VJ Promponas et al.
BIOINFORMATICS (2000)
Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb
BL Wang et al.
CELL (2000)
Cloning, heterologous expression, and enzymological characterization of human squalene monooxygenase
BP Laden et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2000)
Activation of a membrane-bound transcription factor by regulated ubiquitin/proteasome-dependent processing
T Hoppe et al.
CELL (2000)
Cotranslational dimerization of the Rel homology domain of NF-kappa B1 generates p50-p105 heterodimers and is required for effective p50 production
L Lin et al.
EMBO JOURNAL (2000)
Share Paper
