Journal
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
Volume 28, Issue 4, Pages 329-337Publisher
JAPAN ATHEROSCLEROSIS SOC
DOI: 10.5551/jat.56390
Keywords
Proprotein convertase subtilisin/kexin type 9 (PCSK9); Insulin resistance; Lipoprotein(a); Epidemiology
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Funding
- Kimura Memorial Heart Foundation
- Ministry of Education, Culture, Sports, Science and Technology [19K19447]
- Grants-in-Aid for Scientific Research [19K19447] Funding Source: KAKEN
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In a general population sample, serum PCSK9 levels are independently associated with triglycerides, Lp(a) levels, and HOMA-IR, but not with LDL-C levels.
Aim: Proprotein convertase subtilisin/kexin type 9 (PCSK9) has been identified as an important regulator of low-density lipoprotein (LDL) receptor processing. Evolocumab and alirocumab are PCSK9 inhibitors; however, little is known about the association between PCSK9 levels and lipid profiles in a general population. Because PCSK9 inhibitors have LDL-C lowering effects, we investigated whether there is a positive correlation between serum PCSK9 levels and LDL-C or lipoprotein(a) [Lp(a)]. Methods: In Uku town, 674 residents (mean age; 69.2 +/- 8.3 years) received health check-ups. The participants underwent a physical examination and blood tests, including PCSK9 and Lp(a). Serum PCSK9 and Lp(a) were measured by ELISA and Latex methods, respectively. HOMA-IR was calculated by fasting plasma glucose x insulin levels/405. Results: The mean (range) of PCSK9 and Lp(a) were 211.2 (49-601) ng/mL and 60 (1-107) mg/dL, respectively. Because of a skewed distribution, the log-transformed values were used. With univariate linear regression analysis, PCSK9 levels were associated with Lp(a) (p = 0.028), triglycerides (p<0.001), and HOMA-IR (p< 0.001), but not with LDL-C (p = 0.138) levels. Multiple stepwise regression analysis revealed that serum PCSK9 levels were independently associated with triglycerides (p<0.001), Lp(a) (p = 0.033) and HOMA-IR (p = 0.041). Conclusions: PCSK-9 is independently associated with triglycerides, Lp(a) levels, and HOMA-IR, but not LDL-C, in a relatively large general population sample.
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