Journal
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
Volume 24, Issue 4, Pages 328-335Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10286020.2021.1923012
Keywords
Anti-inflammation; composite; ent-kaurane diterpenes; Inula japonica; sesquiterpene dimers
Funding
- Drug Innovation Major Project of China [2018ZX09735001-002-005]
- National Natural Science Foundation of China [81773863]
- Science and Technology Commission of Shanghai Municipality [18401932600]
- Youth Innovation Promotion Association [2019284]
- National Science and Technology Major Project [2019ZX09201004-003-041, 2019ZX09201004-003-042]
- technological innovation action plan of Shanghai Science and Technology Commission [19401971800]
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Phytochemical investigation of the aerial part of Inula japonica led to the isolation of three new compounds, inulanolides F-G (1-2) and 17 alpha-carboxaldehyde-ent-kaur-18-oic acid (3), along with four known compounds (4-7). The new compounds were elucidated using spectroscopic data and showed significant anti-inflammatory activities.
Phytochemical investigation on the 95% alcohol extract of the aerial part of Inula japonica led to the isolation of three new compounds, inulanolides F-G (1-2) and 17 alpha-carboxaldehyde-ent-kaur-18-oic acid (3), together with four known compounds (4-7). The structures of new compounds were elucidated by using spectroscopic data. Most of the isolated compounds showed significant anti-inflammatory activities.
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