Cytotoxic lanostane triterpenoids from the ethanol extract of Schisandra viridis

Three new lanostane triterpenoids, designated as 6-hydroxyl schiglausin A (1), 29-hydroxyl schiglausin D (2), and 6-hydroxyl schiglausin G (3), were isolated from the ethanol extract of the stems of Schisandra viridis. Structural elucidation of all the compounds were performed by spectral methods such as 1D and 2D (H-1-H-1 COSY, HMQC, and HMBC) NMR spectroscopy, in addition to high resolution mass spectrometry. The isolated compounds were tested in vitro for cytotoxic activities. As a result, compound 1 exhibited cytotoxic activities for all six tested human lung cancer cell lines with IC50 values less than 10 mu M.

Automated summary

Three new lanostane triterpenoids were isolated from the stems of Schisandra viridis, with compound 1 showing cytotoxic activities on all six tested human lung cancer cell lines. Structural elucidation was performed using NMR spectroscopy and high resolution mass spectrometry.