Journal
JOURNAL OF APPLIED POLYMER SCIENCE
Volume 138, Issue 30, Pages -Publisher
WILEY
DOI: 10.1002/app.50731
Keywords
nanopesticides delivery system; photodynamic activity; photosensitizer‐ loaded nanoparticles; protoporphyrin IX; UV; esterase responsiveness
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Funding
- Department of Education of Guangdong Province [2018KZDXM051]
- Fundamental Research Funds for the Central Universities [WUT 2020IB031]
- Innovative Research Group Project of the National Natural Science Foundation of China [51373130, 21975057, 51773161]
- Natural Science Foundation of Guangdong Province [2019A1515010921]
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A new strategy combining photodynamic insecticide action and stimulus-responsive polymer micelles has been developed to improve photostability, enhance utilization rate, and reduce pest resistance. The strategy involves the preparation of PBA-modified mPEG conjugate followed by self-assembly to obtain polymeric nanoparticles, which show stability in water but can change structure in response to UV light and/or esterase stimulation. The nanoparticles effectively inhibit the photodegradation of PpIX and exhibit higher phototoxicity to insect cells compared to free PpIX. UV light and/or esterase stimulus can trigger PpIX release, resulting in high photodynamic activity.
To improve photostability and enhance utilization rate and reduce pest resistance, a new strategy based on the combination of photodynamic insecticide action and stimulus-responsive polymer micelles is developed. 4-(phenylazo)benzoic acid (PBA)-modified poly(ethylene glycol) monomethyl ether (mPEG) conjugate is prepared by the esterification reaction of mPEG and PBA, and followed by self-assembly in aqueous solution to obtain polymeric nanoparticles. TEM shows that the nanoparticles have a core-shell structure and an average diameter of 78 nm. DLS shows that the nanoparticles are stability in water solution but can change their structure in response to UV light and/or esterase stimulation. The photodegradation of Protoporphyrin IX (PpIX) encapsulated in the nanoparticles can be effectively inhibited because of aggregation-caused quenching effect, whose maximum photodegradation rate is about 20.54% after 8 h exposure to daylight compared with the complete photodegradation of free PpIX. UV light and/or esterase stimulus can trigger PpIX release and result in a high photodynamic activity. Compared with free PpIX, the PpIX-loaded nanoparticles show a higher phototoxicity to insect cells and the daylight pretreatment has little influence on the phototoxicity.
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