Journal
BRAIN RESEARCH
Volume 1623, Issue -, Pages 150-159Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainres.2015.02.010
Keywords
Stroke; Endothelial progenitor cell; Growth factor; Angiogenesis; Vasculogenesis; Neurorepair
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Funding
- China Scholarship Council (CSC)
- Miguel Servet program from the Spanish Ministry of Health (Instituto de Salud Carlos III) [CP09/00265]
- Fondo de Investigaciones Sanitarias [PI13/01094]
- Spanish stroke research network INVICTUS [RD12/0014/0005]
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Brain injury after ischemia induces the mobilization of endothelial progenitor cells (EPCs), a population of bone marrow-derived cells with angio-vasculogenic capabilities. These cells have been also tested in pre-clinical models and proposed for neurorepair therapy aiming to treat patients in the delayed phases of stroke disease. Promising results in the pre-clinical field encourage the translation into a clinical therapeutic approach. In this review, we will describe EPCs actions for enhanced revascularization and neurorepair, which on one hand are by their direct incorporation into new vascular networks/structures or by direct cell-cell interactions with other brain cells, but also to indirect cell-cell communication thorough EPCs secreted growth factors. All these actions contribute to potentiate neurovascular remodeling and neurorepair. The data presented in this review encourages for a deep understanding of the mechanisms of the cross-talks between EPCs and other brain and progenitor cells, which deserves additional investigations and efforts that may lead to new EPCs-based therapies for stroke patients. This article is part of a Special Issue entitled SI: Cell Interactions In Stroke. (C) 2015 Elsevier B.V. All rights reserved.
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