Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 69, Issue 17, Pages 5013-5025Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.1c00713
Keywords
yellow pea hull; polyphenols; metabolites; organ distribution; antioxidant activity; UHPLC-LTQ-OrbiTrap-MS
Funding
- Agriculture and Agri-Food Canada (AAFC) [J-001322.001.04, 2927]
- Ontario Research fund (ORF) [RE-08-082]
- Saskatchewan Pulse Growers [40004678]
- National Natural Science Foundation of China [82060781]
- China Postdoctoral Science Foundation [2020M671975]
- AAFC
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The study analyzed the chemical profiles, metabolites, and organ distribution of yellow pea hull (YPH) extract, as well as their in vivo antioxidant activities in rats using the D-gal model. Results showed that the distribution of these polyphenol metabolites in plasma and organs may have positive effects on antioxidant enzymes.
As a byproduct, large amounts of yellow pea hull (YPH) are used as low-value or worthless feed worldwide each year, which is a major waste of these polyphenol-rich hulls. The metabolism, bioavailability, and in vivo activities of these polyphenols have not been reported. In the present study, the chemical profiles of YPH extract, their metabolites, and organ distribution were analyzed with UHPLC-LTQ-OrbiTrap-MS, and their in vivo antioxidant activities were studied using the D-gal model in rats. In summary, a total of 42 ingredients were identified in YPH extracts, and 54 metabolites were found in plasma or urine samples. The distribution of metabolites in plasma and organs may have a positive effect on SOD, GSH-Px, MDA, and T-AOC, and the liver and kidneys were the main distribution organs of these metabolites. Our results are of great significance for the development and utilization of the polyphenol-rich hull of yellow pea.
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