Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 69, Issue 17, Pages 5040-5048Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.1c01160
Keywords
Paxillus involutus; chemical composition; 2,5-diarylcyclopentenone derivatives; antioxidant activity
Funding
- National Key Research and Development Program of China [2017YFD0601002]
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Rare compounds with significant antioxidant activities were isolated from wild edible mushrooms, suggesting their potential as effective natural antioxidants with considerable pharmaceutical value.
Wild edible mushrooms are important as a source of nutraceuticals and for the discovery of bioactive metabolites as pharmaceuticals. In this work, 10 rare 2,5-diarylcyclopentenone derivatives were isolated from the wild edible mushroom Paxillus involutus (Batsch) Fr., including eight novel compounds termed involutenone A-H (1-8) and two previously identified compounds (9-10). Their structures were established using high-resolution electrospray ionization mass spectroscopy and 1D and 2D nuclear magnetic resonance data. The absolute configurations of compounds 1-3 and 6-8 were assigned based on the comparison of the experimental and calculated electronic circular dichroism data. The antioxidant activities of 1-8 were tested through DPPH free radical scavenging, hydroxyl radical scavenging, and superoxide anion radical scavenging assays. Compounds 3, 5, 6, and 7 demonstrated significant antioxidant activity compared to the positive control (tert-butylhydroquinone). These compounds could be effective natural antioxidants with considerable pharmaceutical value.
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