Journal
JACC-CARDIOVASCULAR INTERVENTIONS
Volume 14, Issue 6, Pages 595-605Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jcin.2020.12.037
Keywords
continuous coronary thermodilution; coronary microvascular dysfunction; indicator-dilution theory; bolus coronary thermodilution
Categories
Funding
- CardioPaTh
- STAR program of Compagnia di San Paolo
- Abbott
- Hexacath
- Abbott Vascular
- Boston Scientific
- Biotronik
- Medtronic
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This article reviews the methods and clinical applications of coronary microvascular dysfunction, focusing on the use of thermodilution technique to measure coronary flow and microvascular resistance. The authors also discuss the contemporary clinical applications of coronary thermodilution in humans and future perspectives.
Coronary microvascular dysfunction is a highly prevalent condition in both obstructive and nonobstructive coronary artery disease. Intracoronary thermodilution is a promising technique to investigate coronary microvascular (dys)function in vivo and to assess its most important metric: microvascular resistance. Here, the authors provide a practical review of bolus and continuous thermodilution for the measurement of coronary flow and microvascular resistance. The authors describe the basic principles of indicator-dilution theory and of coronary thermodilution and detail the practicalities of their application in the catheterization laboratory. Finally, the authors discuss contemporary clinical applications of coronary thermodilution?based microvascular assessment in humans and future perspectives.
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