Journal
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
Volume 71, Issue 12, Pages 875-885Publisher
TAYLOR & FRANCIS AS
DOI: 10.1080/00914037.2021.1919669
Keywords
Alginate; cellulose; chitosan; osteogenic potential
Categories
Funding
- Sao Paulo Research Foundation (FAPESP) [2017/18782-6, 2016/02811-4, 2019/1189-0, 2018/14840-4]
- National Council for Scientific and Technological Development (CNPq) [307124/2015-0, 303847/2019-0]
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Cell carriers such as chitosan, alginate and cellulose play a critical role in influencing cell behavior and osteogenesis. In a study where rat bone marrow cells were grown on the surface of these polymers, it was found that the nature of the substrate impacted the amount and morphology of the inorganic matrix produced, with perfect hexagonal crystals forming on chitosan, alginate, and cellulose surfaces.
Cell carriers such as chitosan, alginate and cellulose play a crucial role in cell behavior, however the influence of their chemical nature on osteogenesis is little studied. Here, rat bone marrow cells were grown on the surface of those polymers. The cells remained viable and produced a mineral matrix, which was deposited on the surface of all the polymers. The amount of inorganic matrix significantly varied according to the polymer, and the morphology of the inorganic matrix was influenced by the nature of the substrates, generating perfect hexagonal crystals at the surface of chitosan, alginate and cellulose.
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