Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 600, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.ijpharm.2021.120501
Keywords
Fused deposition modeling; 3D printing; Customized dosage forms; Personalized drug delivery; Hot-melt extrusion
Categories
Funding
- National Institute of General Medical Sciences (NIGMS), National Institutes of Health (NIH) as one of its Centers of Biomedical Research Excellence (COBRE) [P30GM122733-01A1]
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Advancements in pharmaceutical technologies have led to the personalization of therapies over the last decade, with 3D printing emerging as a technique for manufacturing complex and customized dosage forms. Among the various 3D printing techniques, fused deposition modeling (FDM) is versatile and cost-effective, particularly in conjunction with hot-melt extrusion (HME) for filament preparation.
Advancements in pharmaceutical technologies have led to the personalization of therapies over the last decade. Three-dimensional printing (3DP) is an emerging technique in the manufacturing of pharmaceutical dosage forms because of its potential to create complex and customized dosage forms according to the patient's needs. Among the various 3DP techniques based on different functioning mechanisms, fused deposition modeling (FDM) 3D printing is a versatile and widely used method with advantages such as precision of quantity and the ability to incorporate different fill densities. This method is also economical and easily produces complex designs. Hot-melt extrusion (HME) is an established technique in pharmaceutical manufacturing that is utilized in the development of filaments which are used as ink roll or feedstock material in FDM 3D printing. This review discusses the various stages involved in FDM 3D printing, including feedstock filament preparation using HME, digital dosage form designs, filament characterization, and various novel applications, and future perspectives.
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