Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 10, Pages -Publisher
MDPI
DOI: 10.3390/ijms22105278
Keywords
exosome; tumor microenvironment; miRNAs; lncRNAs
Funding
- NIH/NCI [R01 CA210192]
- Department of Immunology startup funds
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This review discusses the common isolation and loading methods of exosomes, their major roles in the tumor microenvironment, as well as recent applications of exosomes as drug delivery vessels and the resulting clinical implications.
Exosomes are nanoscale vesicles generated by cells for intercellular communication. Due to their composition, significant research has been conducted to transform these particles into specific delivery systems for various disease states. In this review, we discuss the common isolation and loading methods of exosomes, some of the major roles of exosomes in the tumor microenvironment, as well as discuss recent applications of exosomes as drug delivery vessels and the resulting clinical implications.
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