4.7 Review

The Potential Role of Flavonoids in Ameliorating Diabetic Cardiomyopathy via Alleviation of Cardiac Oxidative Stress, Inflammation and Apoptosis

Journal

Publisher

MDPI
DOI: 10.3390/ijms22105094

Keywords

diastolic dysfunction; flavone; flavonol; flavanol; isoflavone; systolic dysfunction

Funding

  1. Ministry of Education Malaysia [FRGS/1/2019/STG03/UKM/01/3]

Ask authors/readers for more resources

Diabetic cardiomyopathy, a major mortality risk factor among diabetic patients worldwide, is characterized by cardiac structural and functional alterations induced by hyperglycemia-initiated oxidative stress. Flavonoids, the most abundant phytochemicals in plants, have been extensively studied for their therapeutic potential in protecting the heart against diabetes-induced cardiomyopathy through their anti-hyperglycemic, antioxidant, anti-inflammatory, and anti-apoptotic actions.
Diabetic cardiomyopathy is one of the major mortality risk factors among diabetic patients worldwide. It has been established that most of the cardiac structural and functional alterations in the diabetic cardiomyopathy condition resulted from the hyperglycemia-induced persistent oxidative stress in the heart, resulting in the maladaptive responses of inflammation and apoptosis. Flavonoids, the most abundant phytochemical in plants, have been reported to exhibit diverse therapeutic potential in medicine and other biological activities. Flavonoids have been widely studied for their effects in protecting the heart against diabetes-induced cardiomyopathy. The potential of flavonoids in alleviating diabetic cardiomyopathy is mainly related with their remedial actions as anti-hyperglycemic, antioxidant, anti-inflammatory, and anti-apoptotic agents. In this review, we summarize the latest findings of flavonoid treatments on diabetic cardiomyopathy as well as elucidating the mechanisms involved.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available