Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 9, Pages -Publisher
MDPI
DOI: 10.3390/ijms22094984
Keywords
airway; allergy; asthma; epigenetic(-s); exosome; extracellular vesicle (EV); inflammation; microRNA (miRNA); microvesicle (MV)
Funding
- Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) [416910386-GRK 2573/1]
- Deutscher Akademischer Austauschdienst (DAAD, German Academic Exchange Service) [91726294]
- HessenFonds by the Hessen State Ministry for Higher Education, Research and the Arts (HMWK)
- World University Service (WUS)
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Extracellular vesicles play a crucial role in asthma, influencing disease mechanisms and potential therapeutic interventions. EVs also show great potential in the diagnosis of asthma.
Extracellular vesicles (EVs) are membranous structures, which are secreted by almost every cell type analyzed so far. In addition to their importance for cell-cell communication under physiological conditions, EVs are also released during pathogenesis and mechanistically contribute to this process. Here we summarize their functional relevance in asthma, one of the most common chronic non-communicable diseases. Asthma is a complex persistent inflammatory disorder of the airways characterized by reversible airflow obstruction and, from a long-term perspective, airway remodeling. Overall, mechanistic studies summarized here indicate the importance of different subtypes of EVs and their variable cargoes in the functioning of the pathways underlying asthma, and show some interesting potential for the development of future therapeutic interventions. Association studies in turn demonstrate a good diagnostic potential of EVs in asthma.
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