Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 9, Pages -Publisher
MDPI
DOI: 10.3390/ijms22094975
Keywords
targeted toxin; pseudomonas exotoxin; cancer therapy
Funding
- Ministry of Science and Higher Education of the Russian Federation [075-15-2020-773]
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This review discusses the use of protein toxins to target cancer cell receptors for precise therapy, along with the mechanisms of cytotoxic action of various toxins used in modern experimental oncology. The prospects of combined tumor therapy based on multimodal nanostructures are also explored.
Cancer cells frequently overexpress specific surface receptors providing tumor growth and survival which can be used for precise therapy. Targeting cancer cell receptors with protein toxins is an attractive approach widely used in contemporary experimental oncology and preclinical studies. Methods of targeted delivery of toxins to cancer cells, different drug carriers based on nanosized materials (liposomes, nanoparticles, polymers), the most promising designed light-activated toxins, as well as mechanisms of the cytotoxic action of the main natural toxins used in modern experimental oncology, are discussed in this review. The prospects of the combined therapy of tumors based on multimodal nanostructures are also discussed.
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