Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 9, Pages -Publisher
MDPI
DOI: 10.3390/ijms22094792
Keywords
maternal resveratrol; metabolic health; offspring; programming; sex differences
Funding
- Spanish Ministry of Science and Innovation [BFU2017-82565-C21-R2]
- Fondo de Investigacion Sanitaria [PI1900166]
- Centro de Investigacion Biomedica en Red Fisiopatologia de Obesidad y Nutricion (CIBEROBN)
- Instituto de Salud Carlos III
- Fondos FEDER
Ask authors/readers for more resources
Maternal nutritional imbalances, overweight, and obesity can have long-term effects on offspring's metabolic health, increasing the risk of diseases like obesity, diabetes, and cardiovascular issues. Resveratrol, a polyphenolic compound, is believed to provide protective effects against metabolic issues induced by poor dietary habits, although studies on its supplementation during pregnancy are inconclusive. Different responses to metabolic challenges between males and females need further exploration in research.
Maternal nutritional imbalances, in addition to maternal overweight and obesity, can result in long-term effects on the metabolic health of the offspring, increasing the risk of common non-communicable disorders such as obesity, diabetes and cardiovascular disease. This increased disease risk may also be transmitted across generations. Unfortunately, lifestyle interventions have shown reduced compliancy and limited efficacy. Resveratrol is a natural polyphenolic compound reported to have pleiotropic beneficial actions including a possible protective effect against the metabolic programming induced by poor dietary habits during development. However, studies to date are inconclusive regarding the potential metabolic benefits of maternal resveratrol supplementation during pregnancy and lactation on the offspring. Moreover, the responses to metabolic challenges are suggested to be different in males and females, suggesting that the effectiveness of treatment strategies may also differ, but many studies have been performed only in males. Here we review the current evidence, both in humans and animal models, regarding the possible beneficial effects of maternal resveratrol intake on the metabolic health of the offspring and highlight the different effects of resveratrol depending on the maternal diet, as well as the differential responses of males and females.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available