Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 9, Pages -Publisher
MDPI
DOI: 10.3390/ijms22094793
Keywords
mitochondria; mitochondrial function; mitochondrial dysfunction; mitochondrial disease; mitochondrial transplantation
Funding
- KRIBB
- National Research Foundation of Korea [NRF-2019R1A 2C1006035, NRF-2020R1A2C2007111]
- National Research Council of Science & Technology (NST), Republic of Korea [KGC9922113, KGM5432121, KGM5392111] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Mitochondria are vital for cell survival and play essential roles in various cellular functions. Dysfunction in mitochondria is associated with multiple diseases and mitochondrial transplantation is considered a promising therapeutic approach in treating mitochondrial disorders.
Mitochondria are the major source of intercellular bioenergy in the form of ATP. They are necessary for cell survival and play many essential roles such as maintaining calcium homeostasis, body temperature, regulation of metabolism and apoptosis. Mitochondrial dysfunction has been observed in variety of diseases such as cardiovascular disease, aging, type 2 diabetes, cancer and degenerative brain disease. In other words, the interpretation and regulation of mitochondrial signals has the potential to be applied as a treatment for various diseases caused by mitochondrial disorders. In recent years, mitochondrial transplantation has increasingly been a topic of interest as an innovative strategy for the treatment of mitochondrial diseases by augmentation and replacement of mitochondria. In this review, we focus on diseases that are associated with mitochondrial dysfunction and highlight studies related to the rescue of tissue-specific mitochondrial disorders. We firmly believe that mitochondrial transplantation is an optimistic therapeutic approach in finding a potentially valuable treatment for a variety of mitochondrial diseases.
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