Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 9, Pages -Publisher
MDPI
DOI: 10.3390/ijms22094755
Keywords
epitranscriptomics; RNA modifications; tRNA; rRNA
Funding
- AIRC IG 2018 [21406]
- Istituto Pasteur Italia Fondazione Cenci Bolognetti
- Progetti Ateneo Sapienza University of Rome
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RNA modifications play a crucial role in hematopoietic development by acting as post-transcriptional regulators of gene expression, providing an additional level of control. Particularly, the N-6-methylation of adenosine (m(6)A) within mRNA species has been identified as important in regulating hematopoietic differentiation.
Growth and maturation of hematopoietic stem cells (HSCs) are largely controlled at both transcriptional and post-transcriptional levels. In particular, hematopoietic development requires a tight control of protein synthesis. Furthermore, translational deregulation strongly contributes to hematopoietic malignancies. Researchers have recently identified a new layer of gene expression regulation that consists of chemical modification of RNA species, which led to the birth of the epitranscriptomics field. RNA modifications provide an additional level of control in hematopoietic development by acting as post-transcriptional regulators of lineage-specific genetic programs. Other reviews have already described the important role of the N-6-methylation of adenosine (m(6)A) within mRNA species in regulating hematopoietic differentiation and diseases. The aim of this review is to summarize the current status of the role of RNA modifications in the regulation of ribosome function, beyond m(6)A. In particular, we discuss the importance of RNA modifications in tRNA and rRNA molecules. By balancing translational rate and fidelity, they play an important role in regulating normal and malignant hematopoietic development.
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