Related references
Note: Only part of the references are listed.Structural insights into the human D1 and D2 dopamine receptor signaling complexes
Youwen Zhuang et al.
CELL (2021)
Structure of a D2 dopamine receptor-G-protein complex in a lipid membrane
Jie Yin et al.
NATURE (2020)
GPCRmd uncovers the dynamics of the 3D-GPCRome
Ismael Rodriguez-Espigares et al.
NATURE METHODS (2020)
Drug-Target Association Kinetics in Drug Discovery
Adriaan P. IJzerman et al.
TRENDS IN BIOCHEMICAL SCIENCES (2019)
The Beta-Arrestin-Biased Dopamine D2 Receptor Ligand, UNC9994, Is a Partial Agonist at G-Protein-Mediated Potassium Channel Activation
Richard Agren et al.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY (2018)
Adenosine A2A-dopamine D2 receptor heteromers operate striatal function: impact on Parkinson's disease pharmacotherapeutics
Victor Fernandez-Duenas et al.
NEURAL REGENERATION RESEARCH (2018)
Lifetime of muscarinic receptor-G-protein complexes determines coupling efficiency and G-protein subtype selectivity
Olga S. Ilyaskina et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
Reply to 'Antipsychotics with similar association kinetics at dopamine D2 receptors differ in extrapyramidal side-effects'
David A. Sykes et al.
NATURE COMMUNICATIONS (2018)
CHARMM36m: an improved force field for folded and intrinsically disordered proteins
Jing Huang et al.
NATURE METHODS (2017)
Single-molecule imaging reveals receptor-G protein interactions at cell surface hot spots
Titiwat Sungkaworn et al.
NATURE (2017)
Trends in GPCR drug discovery: new agents, targets and indications
Alexander S. Hauser et al.
NATURE REVIEWS DRUG DISCOVERY (2017)
Crystal Structure of an LSD-Bound Human Serotonin Receptor
Daniel Wacker et al.
CELL (2017)
The drug-target residence time model: a 10-year retrospective
Robert A. Copeland
NATURE REVIEWS DRUG DISCOVERY (2016)
Effects of target binding kinetics on in vivo drug efficacy: koff, kon and rebinding
Georges Vauquelin
BRITISH JOURNAL OF PHARMACOLOGY (2016)
The fast-off hypothesis revisited: A functional kinetic study of antipsychotic antagonism of the dopamine D2 receptor
Kristoffer Sahlholm et al.
EUROPEAN NEUROPSYCHOPHARMACOLOGY (2016)
The role of kinetic context in apparent biased agonism at GPCRs
Carmen Klein Herenbrink et al.
NATURE COMMUNICATIONS (2016)
Adrenaline-activated structure of β2-adrenoceptor stabilized by an engineered nanobody
Aaron M. Ring et al.
NATURE (2013)
Agonist high- and low-affinity states of dopamine D2 receptors: methods of detection and clinical implications
Jan-Peter van Wieringen et al.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2013)
Automation of the CHARMM General Force Field (CGenFF) II: Assignment of Bonded Parameters and Partial Atomic Charges
K. Vanommeslaeghe et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2012)
Automation of the CHARMM General Force Field (CGenFF) I: Bond Perception and Atom Typing
K. Vanommeslaeghe et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2012)
Functionally Important Aromatic-Aromatic and Sulfur-π Interactions in the D2 Dopamine Receptor
Kristina N. -M. Daeffler et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)
Increased affinity of dopamine for D2-like versus D1-like receptors. Relevance for volume transmission in interpreting PET findings
Daniel Marcellino et al.
SYNAPSE (2012)
Receptor Conformations Involved in Dopamine D2L Receptor Functional Selectivity Induced by Selected Transmembrane-5 Serine Mutations
J. Corey Fowler et al.
MOLECULAR PHARMACOLOGY (2012)
Agonist-specific voltage sensitivity at the dopamine D2S receptor - Molecular determinants and relevance to therapeutic ligands
Kristoffer Sahlholm et al.
NEUROPHARMACOLOGY (2011)
The Physiology, Signaling, and Pharmacology of Dopamine Receptors
Jean-Martin Beaulieu et al.
PHARMACOLOGICAL REVIEWS (2011)
Co-operativity in agonist binding at the D2 dopamine receptor: evidence from agonist dissociation kinetics
Elodie Kara et al.
JOURNAL OF NEUROCHEMISTRY (2010)
Update of the CHARMM All-Atom Additive Force Field for Lipids: Validation on Six Lipid Types
Jeffery B. Klauda et al.
JOURNAL OF PHYSICAL CHEMISTRY B (2010)
Working with OpusXpress: Methods for high volume oocyte experiments
Roger L. Papke et al.
METHODS (2010)
ACEMD: Accelerating Biomolecular Dynamics in the Microsecond Time Scale
M. J. Harvey et al.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2009)
Probing the role of the cation-π interaction in the binding sites of GPCRs using unnatural amino acids
Michael M. Torrice et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Pharmacological Characterization of 2-Methoxy-N-Propylnorapomorphine's Interactions with D-2 and D-3 Dopamine Receptors
Mette Skinbjerg et al.
SYNAPSE (2009)
Voltage-sensitivity at the human dopamine D2S receptor is agonist-specific
Kristoffer Sahlholm et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2008)
Residence time of receptor-ligand complexes and its effect on biological function
Peter J. Tummino et al.
BIOCHEMISTRY (2008)
Agonist binding, agonist affinity and agonist efficacy at G protein-coupled receptors
P. G. Strange
BRITISH JOURNAL OF PHARMACOLOGY (2008)
Software news and updates - CHARNIM-GUI: A web-based grraphical user interface for CHARMM
Sunhwan Jo et al.
JOURNAL OF COMPUTATIONAL CHEMISTRY (2008)
Differential agonist and inverse agonist profile of antipsychotics at D2L receptors coupled to GIRK potassium channels
Peter Heusler et al.
NEUROPHARMACOLOGY (2007)
Molecular basis of partial agonism at the neurotransmitter α2A-adrenergic receptor and Gi-protein heterotrimer
Viacheslav O. Nikolaev et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Molecular basis of inverse agonism in a G protein-coupled receptor
JP Vilardaga et al.
NATURE CHEMICAL BIOLOGY (2005)
Investigation of the mechanism of agonist and inverse agonist action at D2 dopamine receptors
DJ Roberts et al.
BIOCHEMICAL PHARMACOLOGY (2004)
Gi protein activation in intact cells involves subunit rearrangement rather than dissociation
M Bünemann et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Agonist unbinding from receptor dictates the nature of deactivation kinetics of G protein-gated K+ channels
A Benians et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
The dynamics of formation and action of the ternary complex revealed in living cells using a G-protein-gated K+ channel as a biosensor
A Benians et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Mechanisms of ligand binding and efficacy at the human D2(short) dopamine receptor
SL Payne et al.
JOURNAL OF NEUROCHEMISTRY (2002)
Activation and deactivation kinetics of α2A- and α2C-adrenergic receptor-activated G protein-activated inwardly rectifying K+ channel currents
M Bünemann et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Inhibition by various antipsychotic drugs of the G-protein-activated inwardly rectifying K+ (GIRK) channels expressed in Xenopus oocytes
T Kobayashi et al.
BRITISH JOURNAL OF PHARMACOLOGY (2000)
Effect of multiple serine/alanine mutations in the transmembrane spanning region V of the D-2 dopamine receptor on ligand binding
C Coley et al.
JOURNAL OF NEUROCHEMISTRY (2000)