4.7 Review

Functional Fine-Tuning of Metabolic Pathways by the Endocannabinoid System-Implications for Health and Disease

Related references

Note: Only part of the references are listed.
Article Pathology

Exploring the real-world effect of the SARS-CoV-2 pandemic on the molecular diagnostics for cancer patients and high-risk individuals

Milena Cavic et al.

Summary: The SARS-CoV-2 pandemic had a profound negative impact on the diagnostic output of Serbia's largest molecular diagnostics center for cancer patients and high-risk individuals, but it also resulted in shorter waiting lists for hereditary cancer patients and high-risk individuals.

EXPERT REVIEW OF MOLECULAR DIAGNOSTICS (2021)

Article Neurosciences

Modulation of single cell circadian response to NMDA by diacylglycerol lipase inhibition reveals a role of endocannabinoids in light entrainment of the suprachiasmatic nucleus

Martin Sladek et al.

Summary: The suprachiasmatic nucleus (SCN) of the hypothalamus is a master clock that drives circadian rhythms and adjusts them to external cues. Recent studies suggest that endocannabinoid signaling plays a role in the circadian regulation of the SCN, impacting the response to NMDAR activation. Inhibition of endocannabinoid synthesis enzymes affects the SCN response and individual cell rhythms within the clock center.

NEUROPHARMACOLOGY (2021)

Article Cell Biology

Cannabigerol Is a Potential Therapeutic Agent in a Novel Combined Therapy for Glioblastoma

Tamara T. Lah et al.

Summary: Among primary brain tumors, glioblastoma is the most aggressive and modern therapies have not significantly improved patient survival rates. Recent studies have shown that cannabigerol (CBG) may be a promising alternative to THC for treating glioblastoma, as it has similar anti-tumor effects without the psychoactive side effects. CBG has been found to effectively impair the progression of glioblastoma and destroy therapy-resistant cancer stem cells, suggesting it may have potential as a new adjuvant treatment strategy for this lethal cancer.

CELLS (2021)

Article Oncology

Metabolomics study reveals the potential evidence of metabolic reprogramming towards the Warburg effect in precancerous lesions

Xun Chen et al.

Summary: The study found distinct metabolic characteristics in oral precancerous cells and cervical precancerous lesions compared to normal and cancer cells. Enhanced metabolic activity and increased expression of glycolytic enzymes were observed in cervical precancerous lesions, suggesting metabolic reprogramming may contribute to early tumorigenesis.

JOURNAL OF CANCER (2021)

Review Oncology

Reprogramming of fatty acid metabolism in cancer

Nikos Koundouros et al.

BRITISH JOURNAL OF CANCER (2020)

Editorial Material Pharmacology & Pharmacy

Challenges and opportunities with drug repurposing: finding strategies to find alternative uses of therapeutics

Alan Talevi et al.

EXPERT OPINION ON DRUG DISCOVERY (2020)

Review Biochemistry & Molecular Biology

The Endocannabinoid System: A Target for Cancer Treatment

Chiara Laezza et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Multidisciplinary Sciences

A specific prelimbic-nucleus accumbens pathway controls resilience versus vulnerability to food addiction

Laura Domingo-Rodriguez et al.

NATURE COMMUNICATIONS (2020)

Review Biochemistry & Molecular Biology

Acute inflammation and pathogenesis of SARS-CoV-2 infection: Cannabidiol as a potential anti-inflammatory treatment?

Cecilia T. Costiniuk et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2020)

Review Biochemistry & Molecular Biology

Cannabidiol and Other Non-Psychoactive Cannabinoids for Prevention and Treatment of Gastrointestinal Disorders: Useful Nutraceuticals?

Vicente Martinez et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Biochemistry & Molecular Biology

A Guide to Targeting the Endocannabinoid System in Drug Design

Adam Stasiulewicz et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Endocrinology & Metabolism

Phytocannabinoids: Useful Drugs for the Treatment of Obesity? Special Focus on Cannabidiol

Patrycja Bielawiec et al.

FRONTIERS IN ENDOCRINOLOGY (2020)

Review Oncology

Emerging therapeutic agents for advanced non-small cell lung cancer

Ruqin Chen et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)

Review Multidisciplinary Sciences

Metabolic reprogramming and cancer progression

Brandon Faubert et al.

SCIENCE (2020)

Editorial Material Pharmacology & Pharmacy

Editorial: The Canonical and Non-Canonical Endocannabinoid System as a Target in Cancer and Acute and Chronic Pain

Marialessandra Contino et al.

FRONTIERS IN PHARMACOLOGY (2020)

Review Biochemistry & Molecular Biology

The Double-Faced Role of Nitric Oxide and Reactive Oxygen Species in Solid Tumors

Sanja Mijatovic et al.

ANTIOXIDANTS (2020)

Review Biochemistry & Molecular Biology

Targeting Cannabinoid Receptors: Current Status and Prospects of Natural Products

Dongchen An et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Biochemistry & Molecular Biology

Cannabis, the Endocannabinoid System and Immunity-the Journey from the Bedside to the Bench and Back

Osnat Almogi-Hazan et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Biochemistry & Molecular Biology

The Immune Endocannabinoid System of the Tumor Microenvironment

Melanie Kienzl et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Pharmacology & Pharmacy

Challenges for Drug Repurposing in the COVID-19 Pandemic Era

Janet Sultana et al.

FRONTIERS IN PHARMACOLOGY (2020)

Article Biochemistry & Molecular Biology

Cannabinoid receptor 2 deficiency exacerbates inflammation and neutrophil recruitment

Theodore S. Kapellos et al.

FASEB JOURNAL (2019)

Article Biochemistry & Molecular Biology

Cannabinoids Reduce Inflammation but Inhibit Lymphocyte Recovery in Murine Models of Bone Marrow Transplantation

Iman Khuja et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Multidisciplinary Sciences

Therapeutic targeting of HER2-CB2R heteromers in HER2-positive breast cancer

Sandra Blasco-Benito et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Review Pharmacology & Pharmacy

The Endocannabinoid System as a Target in Cancer Diseases: Are We There Yet?

Estefania Moreno et al.

FRONTIERS IN PHARMACOLOGY (2019)

Review Biochemistry & Molecular Biology

Endocannabinoid and Prostanoid Crosstalk in Pain

Baptiste Buisseret et al.

TRENDS IN MOLECULAR MEDICINE (2019)

Article Biochemistry & Molecular Biology

Emerging class of omega-3 fatty acid endocannabinoids & their derivatives

Josephine E. Watson et al.

PROSTAGLANDINS & OTHER LIPID MEDIATORS (2019)

Review Endocrinology & Metabolism

The Expanded Endocannabinoid System/Endocannabinoidome as a Potential Target for Treating Diabetes Mellitus

Alain Veilleux et al.

CURRENT DIABETES REPORTS (2019)

Review Nutrition & Dietetics

Lifestyle and Metabolic Syndrome: Contribution of the Endocannabinoidome

Vincenzo Di Marzo et al.

NUTRIENTS (2019)

Article Pharmacology & Pharmacy

Cannabidiol reduces airway inflammation and fibrosis in experimental allergic asthma

Francieli Vuolo et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2019)

Review Biochemistry & Molecular Biology

Endocannabinoid System in the Airways

Turgut Emrah Bozkurt

MOLECULES (2019)

Review Immunology

Anti-inflammatory mechanisms of cannabinoids: an immunometabolic perspective

G. van Niekerk et al.

INFLAMMOPHARMACOLOGY (2019)

Review Medicine, General & Internal

Association Between Marijuana Use and Risk of Cancer A Systematic Review and Meta-analysis

Mehrnaz Ghasemiesfe et al.

JAMA NETWORK OPEN (2019)

Review Allergy

Cannabis-Associated Asthma and Allergies

J. M. Chatkin et al.

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY (2019)

Article Oncology

Agonist-induced CXCR4 and CB2 Heterodimerization Inhibits Gα13/RhoA-mediated Migration

Kisha A. Scarlett et al.

MOLECULAR CANCER RESEARCH (2018)

Article Medicine, Research & Experimental

Intestinal P-glycoprotein exports endocannabinoids to prevent inflammation and maintain homeostasis

Rose L. Szabady et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

Article Medicine, Research & Experimental

The exogenous administration of CB2 specific agonist, GW405833, inhibits inflammation by reducing cytokine production and oxidative stress

Ali Parlar et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2018)

Review Pharmacology & Pharmacy

Medical Use of Cannabinoids

Ana Isabel Fraguas-Sanchez et al.

DRUGS (2018)

Review Immunology

Endocannabinoids and related N-acylethanolamines: biological activities and metabolism

Kazuhito Tsuboi et al.

INFLAMMATION AND REGENERATION (2018)

Article Respiratory System

CB2R agonist prevents nicotine induced lung fibrosis

Ewelina Wawryk-Gawda et al.

EXPERIMENTAL LUNG RESEARCH (2018)

Article Pharmacology & Pharmacy

Synthetic Cannabinoid Activity Against Colorectal Cancer Cells

Wesley M. Raup-Konsavage et al.

CANNABIS AND CANNABINOID RESEARCH (2018)

Review Endocrinology & Metabolism

MECHANISMS IN ENDOCRINOLOGY Endocannabinoids and metabolism: past, present and future

Vincent Simon et al.

EUROPEAN JOURNAL OF ENDOCRINOLOGY (2017)

Article Agricultural Engineering

Cytotoxic activity of Nepeta rtanjensis Diklic & Milojevic essential oil and its mode of action

Marijana Skoric et al.

INDUSTRIAL CROPS AND PRODUCTS (2017)

Article Pharmacology & Pharmacy

Pharmacological inhibition of MAGL attenuates experimental colon carcinogenesis

Ester Pagano et al.

PHARMACOLOGICAL RESEARCH (2017)

Article Multidisciplinary Sciences

A pathology atlas of the human cancer transcriptome

Mathias Uhlen et al.

SCIENCE (2017)

Article Multidisciplinary Sciences

Iscador Qu inhibits doxorubicin-induced senescence of MCF7 cells

T. Srdic-Rajic et al.

SCIENTIFIC REPORTS (2017)

Article Medicine, Research & Experimental

Cannabinoid CB1 receptor overactivity contributes to the pathogenesis of idiopathic pulmonary fibrosis

Resat Cinar et al.

JCI INSIGHT (2017)

Review Pharmacology & Pharmacy

Role of the endocannabinoid system in diabetes and diabetic complications

G. Gruden et al.

BRITISH JOURNAL OF PHARMACOLOGY (2016)

Article Nutrition & Dietetics

Responses of peripheral endocannabinoids and endocannabinoid-related compounds to hedonic eating in obesity

A. M. Monteleone et al.

EUROPEAN JOURNAL OF NUTRITION (2016)

Review Pharmacology & Pharmacy

Phyto-, endo- and synthetic cannabinoids: promising chemotherapeutic agents in the treatment of breast and prostate carcinomas

A. I. Fraguas-Sanchez et al.

EXPERT OPINION ON INVESTIGATIONAL DRUGS (2016)

Review Biochemistry & Molecular Biology

Hemopressin Peptides as Modulators of the Endocannabinoid System and their Potential Applications as Therapeutic Tools

Giorgia Macedonio et al.

PROTEIN AND PEPTIDE LETTERS (2016)

Article Endocrinology & Metabolism

Sleep restriction alters plasma endocannabinoids concentrations before but not after exercise in humans

Jonathan Cedernaes et al.

PSYCHONEUROENDOCRINOLOGY (2016)

Review Endocrinology & Metabolism

Disturbances of sleep and circadian rhythms: novel risk factors for obesity

Josiane L. Broussard et al.

CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY (2016)

Article Biotechnology & Applied Microbiology

Circulating Endocannabinoids and Insulin Resistance in Patients with Obstructive Sleep Apnea

Xiaoya Wang et al.

BIOMED RESEARCH INTERNATIONAL (2016)

Article Pharmacology & Pharmacy

Impact of Cannabis, Cannabinoids, and Endocannabinoids in the Lungs

Caroline Turcotte et al.

FRONTIERS IN PHARMACOLOGY (2016)

Review Immunology

Endocannabinoid signalling in innate and adaptive immunity

Valerio Chiurchiu et al.

IMMUNOLOGY (2015)

Review Neurosciences

The Antitumor Activity of Plant-Derived Non-Psychoactive Cannabinoids

Sean D. McAllister et al.

JOURNAL OF NEUROIMMUNE PHARMACOLOGY (2015)

Article Oncology

Proapoptotic effect of endocannabinoids in prostate cancer cells

O. Orellana-Serradell et al.

ONCOLOGY REPORTS (2015)

Article Multidisciplinary Sciences

Fetal endocannabinoids orchestrate the organization of pancreatic islet microarchitecture

Katarzyna Malenczyk et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Review Economics

The Epidemiology of Obesity: A Big Picture

Adela Hruby et al.

PHARMACOECONOMICS (2015)

Article Biochemistry & Molecular Biology

Targeting CB2-GPR55 Receptor Heteromers Modulates Cancer Cell Signaling

Estefania Moreno et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Article Neurosciences

The endocannabinoid system controls food intake via olfactory processes

Edgar Soria-Gomez et al.

NATURE NEUROSCIENCE (2014)

Article Multidisciplinary Sciences

Pregnenolone Can Protect the Brain from Cannabis Intoxication

Monique Vallee et al.

SCIENCE (2014)

Article Neurosciences

Cannabinoids Inhibit T-cells via Cannabinoid Receptor 2 in an In Vitro Assay for Graft Rejection, the Mixed Lymphocyte Reaction

Rebecca Hartzell Robinson et al.

JOURNAL OF NEUROIMMUNE PHARMACOLOGY (2013)

Article Biochemistry & Molecular Biology

Chronic treatment with krill powder reduces plasma triglyceride and anandamide levels in mildly obese men

Kjetil Berge et al.

LIPIDS IN HEALTH AND DISEASE (2013)

Article Neurosciences

Central functional response to the novel peptide cannabinoid, hemopressin

Garron T. Dodd et al.

NEUROPHARMACOLOGY (2013)

Review Oncology

Cannabinoids: A new hope for breast cancer therapy?

Maria M. Caffarel et al.

CANCER TREATMENT REVIEWS (2012)

Article Endocrinology & Metabolism

Simultaneous postprandial deregulation of the orexigenic endocannabinoid anandamide and the anorexigenic peptide YY in obesity

B. Gatta-Cherifi et al.

INTERNATIONAL JOURNAL OF OBESITY (2012)

Article Neurosciences

CB1 Agonist ACEA Protects Neurons and Reduces the Cognitive Impairment of AβPP/PS1 Mice

Ester Aso et al.

JOURNAL OF ALZHEIMERS DISEASE (2012)

Article Endocrinology & Metabolism

Hedonic Eating Is Associated with Increased Peripheral Levels of Ghrelin and the Endocannabinoid 2-Arachidonoyl-Glycerol in Healthy Humans: A Pilot Study

Palmiero Monteleone et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2012)

Review Oncology

Tumor cell metabolism An integral view

Susana Romero-Garcia et al.

CANCER BIOLOGY & THERAPY (2011)

Article Cell Biology

GPR55 regulates cannabinoid 2 receptor-mediated responses in human neutrophils

Nariman A. B. Balenga et al.

CELL RESEARCH (2011)

Article Endocrinology & Metabolism

Central and Peripheral Endocannabinoids and Cognate Acylethanolamides in Humans: Association with Race, Adiposity, and Energy Expenditure

Reiner Jumpertz et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2011)

Article Biochemical Research Methods

Production of functional recombinant G-protein coupled receptors for heteromerization studies

Milena Cavic et al.

JOURNAL OF NEUROSCIENCE METHODS (2011)

Review Endocrinology & Metabolism

Rimonabant: FromRIO to Ban

Amir H. Sam et al.

JOURNAL OF OBESITY (2011)

Article Neurosciences

Ghrelin Increases the Rewarding Value of High-Fat Diet in an Orexin-Dependent Manner

Mario Perello et al.

BIOLOGICAL PSYCHIATRY (2010)

Article Endocrinology & Metabolism

Cannabinoid type 1 receptor blockade induces transdifferentiation towards a brown fat phenotype in white adipocytes

N. Perwitz et al.

DIABETES OBESITY & METABOLISM (2010)

Article Medicine, Research & Experimental

Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity

Joseph Tam et al.

JOURNAL OF CLINICAL INVESTIGATION (2010)

Article Biochemistry & Molecular Biology

Cannabinoids reduce ErbB2-driven breast cancer progression through Akt inhibition

Maria M. Caffarel et al.

MOLECULAR CANCER (2010)

Article Neurosciences

Bimodal control of stimulated food intake by the endocannabinoid system

Luigi Bellocchio et al.

NATURE NEUROSCIENCE (2010)

Review Behavioral Sciences

The endocannabinoid system, eating behavior and energy homeostasis: The end or a new beginning?

F. J. Bermudez-Silva et al.

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2010)

Article Multidisciplinary Sciences

Endocannabinoids selectively enhance sweet taste

Ryusuke Yoshida et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Endocrinology & Metabolism

The role of the endocannabinoid system in lipogenesis and fatty acid metabolism

Roberto Vettor et al.

BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM (2009)

Article Endocrinology & Metabolism

Role of insulin as a negative regulator of plasma endocannabinoid levels in obese and nonobese subjects

Vincenzo Di Marzo et al.

EUROPEAN JOURNAL OF ENDOCRINOLOGY (2009)

Article Biochemistry & Molecular Biology

Cannabinoid Receptor Type 1-and 2-mediated Increase in Cyclic AMP Inhibits T Cell Receptor-triggered Signaling

Christine Boerner et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Oncology

Synthetic cannabinoid receptor agonists inhibit tumor growth and metastasis of breast cancer

Zahida Qamri et al.

MOLECULAR CANCER THERAPEUTICS (2009)

Article Anesthesiology

Therapeutic potential of cannabis in pain medicine

R. D. Hosking et al.

BRITISH JOURNAL OF ANAESTHESIA (2008)

Article Biochemistry & Molecular Biology

Leptin controls adipose tissue lipogenesis via central, STAT3-independent mechanisms

Christoph Buettner et al.

NATURE MEDICINE (2008)

Article Endocrinology & Metabolism

Activation of human T cells induces upregulation of cannabinoid receptor type 1 transcription

Christine Boerner et al.

NEUROIMMUNOMODULATION (2008)

Review Pharmacology & Pharmacy

The complications of promiscuity: endocannabinoid action and metabolism

S. P. H. Alexander et al.

BRITISH JOURNAL OF PHARMACOLOGY (2007)

Article Multidisciplinary Sciences

Hemopressin is an inverse agonist of CB1 cannabinoid receptors

Andrea S. Heimann et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Endocrinology & Metabolism

The endogenous cannabinoid system stimulates glucose uptake in human fat cells via phosphatidylinositol 3-kinase and calcium-dependent mechanisms

Claudio Pagano et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2007)

Article Immunology

Anandamide and Δ9-tetrahydrocannabinol directly inhibit cells of the immune system via CB2 receptors

Toby K. Eisenstein et al.

JOURNAL OF NEUROIMMUNOLOGY (2007)

Article Neurosciences

Cannabinoids and gliomas

Guillermo Velasco et al.

MOLECULAR NEUROBIOLOGY (2007)

Article Endocrinology & Metabolism

Circulating endocannabinoid levels, abdominal adiposity and related cardiometabolic risk factors in obese men

M. Cote et al.

INTERNATIONAL JOURNAL OF OBESITY (2007)

Article Endocrinology & Metabolism

Regulation, function, and dysregulation of endocannabinoids in models of adipose and β-pancreatic cells and in obesity and hyperglycemia

Isabel Matias et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2006)

Article Endocrinology & Metabolism

Endogenous cannabinoids in the brain and peripheral tissues: regulation of their levels and control of food intake

I Matias et al.

INTERNATIONAL JOURNAL OF OBESITY (2006)

Article Endocrinology & Metabolism

Activation of the peripheral endocannabinoid system in human obesity

S Engeli et al.

DIABETES (2005)

Article Pharmacology & Pharmacy

Anandamide induced PPARγ transcriptional activation and 3T3-L1 preadipocyte differentiation

M Bouaboula et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2005)

Article Medicine, Research & Experimental

Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity

D Osei-Hyiaman et al.

JOURNAL OF CLINICAL INVESTIGATION (2005)

Review Immunology

Cannabinoid-based drugs as anti-inflammatory therapeutics

TW Klein

NATURE REVIEWS IMMUNOLOGY (2005)

Review Biochemistry & Molecular Biology

Cannabinoid receptors and their ligands

RG Pertwee et al.

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS (2002)