Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 9, Pages -Publisher
MDPI
DOI: 10.3390/ijms22094874
Keywords
hypoxia; cell cycle; HIF; PHDs; 2-OGDs; mitosis
Funding
- Wellcome Trust [206293/Z/17/Z] Funding Source: Medline
- Tertiary Education Trust Fund [Temitope Fasanya] Funding Source: Medline
- Wellcome Trust [206293/Z/17/Z] Funding Source: Wellcome Trust
Ask authors/readers for more resources
The cell cycle is a crucial cellular process for genome replication, with mechanisms needed to respond to stress signals like hypoxia. This review discusses the interplay between transcriptional and post-transcriptional mechanisms initiated under hypoxia and cell cycle control. Overall, the relationship between the cellular response to hypoxia and the cell cycle ensures survival and minimizes errors during cell division.
The cell cycle is an important cellular process whereby the cell attempts to replicate its genome in an error-free manner. As such, mechanisms must exist for the cell cycle to respond to stress signals such as those elicited by hypoxia or reduced oxygen availability. This review focuses on the role of transcriptional and post-transcriptional mechanisms initiated in hypoxia that interface with cell cycle control. In addition, we discuss how the cell cycle can alter the hypoxia response. Overall, the cellular response to hypoxia and the cell cycle are linked through a variety of mechanisms, allowing cells to respond to hypoxia in a manner that ensures survival and minimal errors throughout cell division.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available