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BIOENGINEERED (2016)
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Kyunghun Min et al.
MSPHERE (2016)
Inhibition of HSV-1 Replication by Gene Editing Strategy
Pamela C. Roehm et al.
SCIENTIFIC REPORTS (2016)
CRISPR/Cas9-mediated efficient targeted mutagenesis in Chardonnay (Vitis vinifera L.)
Chong Ren et al.
SCIENTIFIC REPORTS (2016)
A 'suicide' CRISPR-Cas9 system to promote gene deletion and restoration by electroporation in Cryptococcus neoformans
Yu Wang et al.
SCIENTIFIC REPORTS (2016)
Development of Commercial Thermo-sensitive Genic Male Sterile Rice Accelerates Hybrid Rice Breeding Using the CRISPR/Cas9-mediated TMS5 Editing System
Hai Zhou et al.
SCIENTIFIC REPORTS (2016)
Gene replacements and insertions in rice by intron targeting using CRISPR-Cas9
Jun Li et al.
NATURE PLANTS (2016)
One-step high-efficiency CRISPR/Cas9-mediated genome editing in Streptomyces
He Huang et al.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2015)
Multigene Editing in the Escherichia coli Genome via the CRISPR-Cas9 System
Yu Jiang et al.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2015)
CRISPR/Cas9-mediated mutagenesis of the RIN locus that regulates tomato fruit ripening
Yasuhiro Ito et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015)
No time to waste-the ethical challenges created by CRISPR CRISPR/Cas, being an efficient, simple, and cheap technology to edit the genome of any organism, raises many ethical and regulatory issues beyond the use to manipulate human germ line cells
Arthur L. Caplan et al.
EMBO REPORTS (2015)
Development of the CRISPR/Cas9 System for Targeted Gene Disruption in Aspergillus fumigatus
Kevin K. Fuller et al.
EUKARYOTIC CELL (2015)
CRISPR-mediated genotypic and phenotypic correction of a chronic granulomatous disease mutation in human iPS cells
Rowan Flynn et al.
EXPERIMENTAL HEMATOLOGY (2015)
Current and future delivery systems for engineered nucleases: ZFN, TALEN and RGEN
Qurrat Ul Ain et al.
JOURNAL OF CONTROLLED RELEASE (2015)
New approaches to gene and cell therapy for hemophilia
T. Ohmori et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2015)
Metabolic engineering of Escherichia coli using CRISPR-Cas9 meditated genome editing
Yifan Li et al.
METABOLIC ENGINEERING (2015)
Multiplex metabolic pathway engineering using CRISPR/Cas9 in Saccharomyces cerevisiae
Tadas Jakounas et al.
METABOLIC ENGINEERING (2015)
A Robust CRISPR/Cas9 System for Convenient, High-Efficiency Multiplex Genome Editing in Monocot and Dicot Plants
Xingliang Ma et al.
MOLECULAR PLANT (2015)
BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis
Matthew C. Canver et al.
NATURE (2015)
An updated evolutionary classification of CRISPR-Cas systems
Kira S. Makarova et al.
NATURE REVIEWS MICROBIOLOGY (2015)
Temperate and lytic bacteriophages programmed to sensitize and kill antibiotic-resistant bacteria
Ido Yosef et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Cutting it close: CRISPR-associated endoribonuclease structure and function
Megan L. Hochstrasser et al.
TRENDS IN BIOCHEMICAL SCIENCES (2015)
Cellulosome stoichiometry in Clostridium cellulolyticum is regulated by selective RNA processing and stabilization
Chenggang Xu et al.
NATURE COMMUNICATIONS (2015)
A geminivirus-based guide RNA delivery system for CRISPR/Cas9 mediated plant genome editing
Kangquan Yin et al.
SCIENTIFIC REPORTS (2015)
Genome editing of CXCR4 by CRISPR/cas9 confers cells resistant to HIV-1 infection
Panpan Hou et al.
SCIENTIFIC REPORTS (2015)
Functional Gene Correction for Cystic Fibrosis in Lung Epithelial Cells Generated from Patient iPSCs
Amy L. Firth et al.
CELL REPORTS (2015)
Precise Correction of the Dystrophin Gene in Duchenne Muscular Dystrophy Patient Induced Pluripotent Stem Cells by TALEN and CRISPR-Cas9
Hongmei Lisa Li et al.
STEM CELL REPORTS (2015)
Conferring resistance to geminiviruses with the CRISPR-Cas prokaryotic immune system
Nicholas J. Baltes et al.
NATURE PLANTS (2015)
Efficient Multiplexed Integration of Synergistic Alleles and Metabolic Pathways in Yeasts via CRISPR-Cas
Andrew A. Horwitz et al.
CELL SYSTEMS (2015)
Efficient genome editing in filamentous fungus Trichoderma reesei using the CRISPR/Cas9 system
Rui Liu et al.
CELL DISCOVERY (2015)
Therapeutic Targeting of Tumor Suppressor Genes
Luc G. T. Morris et al.
CANCER (2015)
Correction of a genetic disease by CRISPR-Cas9-mediated gene editing in mouse spermatogonial stem cells
Yuxuan Wu et al.
CELL RESEARCH (2015)
CRISPR/Cas9-Mediated Genome Editing in Soybean Hairy Roots
Yupeng Cai et al.
PLOS ONE (2015)
A CRISPR-Cas9 System for Genetic Engineering of Filamentous Fungi
Christina S. Nodvig et al.
PLOS ONE (2015)
CRISPR/Cas9 System as an Agent for Eliminating Polyomavirus JC Infection
Hassen S. Wollebo et al.
PLOS ONE (2015)
Biogenesis pathways of RNA guides in archaeal and bacterial CRISPR-Cas adaptive immunity
Emmanuelle Charpentier et al.
FEMS MICROBIOLOGY REVIEWS (2015)
In vitro and in vivo growth suppression of human papillomavirus 16-positive cervical cancer cells by CRISPR/Cas9
Shuai Zhen et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2014)
Analysis of off-target effects of CRISPR/Cas-derived RNA-guided endonucleases and nickases
Seung Woo Cho et al.
GENOME RESEARCH (2014)
Exploiting CRISPR-Cas nucleases to produce sequence-specific antimicrobials
David Bikard et al.
NATURE BIOTECHNOLOGY (2014)
Genome editing in rice and wheat using the CRISPR/Cas system
Qiwei Shan et al.
NATURE PROTOCOLS (2014)
CRISPR-Cas9-assisted recombineering in Lactobacillus reuteri
Jee-Hwan Oh et al.
NUCLEIC ACIDS RESEARCH (2014)
The CRISPR/Cas9 system produces specific and homozygous targeted gene editing in rice in one generation
Hui Zhang et al.
PLANT BIOTECHNOLOGY JOURNAL (2014)
Efficient Gene Editing in Tomato in the First Generation Using the Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR-Associated9 System
Christopher Brooks et al.
PLANT PHYSIOLOGY (2014)
RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection
Wenhui Hu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Improving fatty acids production by engineering dynamic pathway regulation and metabolic control
Peng Xu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Multigeneration analysis reveals the inheritance, specificity, and patterns of CRISPR/Cas-induced gene modifications in Arabidopsis
Zhengyan Feng et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Gene targeting using the Agrobacterium tumefaciens-mediated CRISPR-Cas system in rice
Rongfang Xu et al.
RICE (2014)
Programmable Removal of Bacterial Strains by Use of Genome-Targeting CRISPR-Cas Systems
Ahmed A. Gomaa et al.
MBIO (2014)
Implementation of the CRISPR-Cas9 system in fission yeast
Jake Z. Jacobs et al.
NATURE COMMUNICATIONS (2014)
Multiplex genome engineering in human cells using all-in-one CRISPR/Cas9 vector system
Tetsushi Sakuma et al.
SCIENTIFIC REPORTS (2014)
Targeted mutagenesis in rice using CRISPR-Cas system
Jin Miao et al.
CELL RESEARCH (2013)
Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease
Seung Woo Cho et al.
NATURE BIOTECHNOLOGY (2013)
High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells
Yanfang Fu et al.
NATURE BIOTECHNOLOGY (2013)
Targeted genome modification of crop plants using a CRISPR-Cas system
Qiwei Shan et al.
NATURE BIOTECHNOLOGY (2013)
Programmable repression and activation of bacterial gene expression using an engineered CRISPR-Cas system
David Bikard et al.
NUCLEIC ACIDS RESEARCH (2013)
The Development of C4 Rice: Current Progress and Future Challenges
Susanne von Caemmerer et al.
SCIENCE (2012)
A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity
Martin Jinek et al.
SCIENCE (2012)
RNA in Defense: CRISPRs Protect Prokaryotes against Mobile Genetic Elements
Matthijs M. Jore et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2012)
HIV DNA Integration
Robert Craigie et al.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)
Virus reactivation: a panoramic view in human infections
Christopher M. Traylen et al.
FUTURE VIROLOGY (2011)
Evolution and classification of the CRISPR-Cas systems
Kira S. Makarova et al.
NATURE REVIEWS MICROBIOLOGY (2011)
Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting
Tomas Cermak et al.
NUCLEIC ACIDS RESEARCH (2011)
The Streptococcus thermophilus CRISPR/Cas system provides immunity in Escherichia coli
Rimantas Sapranauskas et al.
NUCLEIC ACIDS RESEARCH (2011)
Progress in hematopoietic stem cell transplantation as allogeneic cellular gene therapy in thalassemia
Antonella Isgro et al.
COOLEY'S ANEMIA: NINTH SYMPOSIUM (2010)
Targeting DNA Double-Strand Breaks with TAL Effector Nucleases
Michelle Christian et al.
GENETICS (2010)
The CRISPR System: Small RNA-Guided Defense in Bacteria and Archaea
Fedor V. Karginov et al.
MOLECULAR CELL (2010)
CRISPR provides acquired resistance against viruses in prokaryotes
Rodolphe Barrangou et al.
SCIENCE (2007)
A putative RNA-interference-based immune system in prokaryotes: computational analysis of the predicted enzymatic machinery, functional analogies with eukaryotic RNAi, and hypothetical mechanisms of action
Kira S. Makarova et al.
BIOLOGY DIRECT (2006)
CRISPR elements in Yersinia pestis acquire new repeats by preferential uptake of bacteriophage DNA, and provide additional tools for evolutionary studies
C Pourcel et al.
MICROBIOLOGY-SGM (2005)
Intervening sequences of regularly spaced prokaryotic repeats derive from foreign genetic elements
FJM Mojica et al.
JOURNAL OF MOLECULAR EVOLUTION (2005)
A DNA repair system specific for thermophilic Archaea and bacteria predicted by genomic context analysis
KS Makarova et al.
NUCLEIC ACIDS RESEARCH (2002)
Identification of genes that are associated with DNA repeats in prokaryotes
R Jansen et al.
MOLECULAR MICROBIOLOGY (2002)
Biological significance of a family of regularly spaced repeats in the genomes of Archaea, bacteria and mitochondria
FJM Mojica et al.
MOLECULAR MICROBIOLOGY (2000)