Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 6, Pages -Publisher
MDPI
DOI: 10.3390/ijms22063137
Keywords
long non-coding RNA; hepatocellular carcinoma; cancer hallmarks; biomarkers; therapeutic strategies; HBV; HCV infections
Funding
- Hong Kong Research Grant Council-Theme-based Research Scheme [T12-704/16-R]
- Hong Kong Health and Medical Research Fund [04150776]
- University of Hong Kong Seed Fund for Translational and Applied Research [201910160019]
- State Key Laboratory of Liver Research-Innovative Research Fund 2018
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Hepatocellular carcinoma (HCC) is a common malignancy associated with HBV/HCV infections, cirrhosis, and fatty liver diseases. The discovery of long noncoding RNAs (lncRNAs) has revealed their crucial roles in gene regulation, suggesting their potential as prognostic markers and therapeutic targets for HCC. Research on the regulatory roles of lncRNAs in HCC is shedding light on future therapeutic applications.
Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies worldwide. HCC is associated with several etiological factors, including HBV/HCV infections, cirrhosis, and fatty liver diseases. However, the molecular mechanism underlying HCC development remains largely elusive. The advent of high-throughput sequencing has unveiled an unprecedented discovery of a plethora of long noncoding RNAs (lncRNAs). Despite the lack of coding capacity, lncRNAs have key roles in gene regulation through interacting with various biomolecules. It is increasingly evident that the dysregulation of lncRNAs is inextricably linked to HCC cancer phenotypes, suggesting that lncRNAs are potential prognostic markers and therapeutic targets. In light of the emerging research in the study of the regulatory roles of lncRNAs in HCC, we discuss the association of lncRNAs with HCC. We link the biological processes influenced by lncRNAs to cancer hallmarks in HCC and describe the associated functional mechanisms. This review sheds light on future research directions, including the potential therapeutic applications of lncRNAs.
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