How Can a Polymeric Formula Induce Remission in Crohn's Disease Patients?

Crohn's disease is an inflammatory bowel disease whose prevalence is increasing worldwide. Among medical strategies, dietary therapy with exclusive enteral nutrition is recommended as a first-line option, at least for children, because it induces clinical remission and mucosal healing. Modulen(R), a polymeric TGF-beta 2 enriched formula, has good palatability and is widely used. For the first time in the literature, this review outlines and discusses the clinical outcomes obtained with this therapy, as well as the potential mechanisms of action of its compounds. It can be explained by its TGF-beta 2 content, but also by its protein and lipid composition. Further well-designed studies are required to improve our knowledge and to optimize therapeutic strategies.

Automated summary

Crohn's disease, an inflammatory bowel disease, is on the rise globally. Dietary therapy with Modulen(R), a formula enriched with polymeric TGF-beta 2, is recommended as a first-line option for inducing clinical remission and mucosal healing, especially for children. Further well-designed studies are needed to improve knowledge and optimize therapeutic strategies.