Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 10, Pages -Publisher
MDPI
DOI: 10.3390/ijms22105236
Keywords
tissue engineering; regenerative medicine; biomaterials; biocompatibility; scaffold; tissue repair; dentistry
Funding
- Ministry of Health, Italy, of IRCCS Centro Neurolesi Bonino Pulejo
- [OT60/2018]
- [FD60/2020]
- [GDM60/2019]
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Tissue engineering has become a major focus of research, with the potential of biomaterials and mesenchymal stem cells (MSCs) showing promise for bone regeneration, particularly in oral bone regeneration. Combining MSCs with biomaterials enhances bone regenerative power, and utilizing the MSC secretome also presents a promising future for bone tissue regeneration.
In the last few decades, tissue engineering has become one of the most studied medical fields. Even if bone shows self-remodeling properties, in some cases, due to injuries or anomalies, bone regeneration can be required. In particular, oral bone regeneration is needed in the dentistry field, where the functional restoration of tissues near the tooth represents a limit for many dental implants. In this context, the application of biomaterials and mesenchymal stem cells (MSCs) appears promising for bone regeneration. This review focused on in vivo studies that evaluated bone regeneration using biomaterials with MSCs. Different biocompatible biomaterials were enriched with MSCs from different sources. These constructs showed an enhanced bone regenerative power in in vivo models. However, we discussed also a future perspective in tissue engineering using the MSC secretome, namely the conditioned medium and extracellular vesicles. This new approach has already shown promising results for bone tissue regeneration in experimental models.
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