Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/ijms22083854
Keywords
intestinal microbiota; acceptive immunity; immune tolerance; fucose; fucosylated glycans; host– microbiome interactions
Funding
- Russian Science Foundation [20-65-47026]
- Russian Science Foundation [20-65-47026] Funding Source: Russian Science Foundation
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This article mainly discusses the impact of the relationship between the human body and symbiotic microbiota on the growth of chronic non-communicable diseases, emphasizing the importance of the balance between the immune system and the microbiota on disease mechanisms, as well as the role of milk glycans, mucins, and secretory immunoglobulins in maintaining homeostasis.
The growth in the number of chronic non-communicable diseases in the second half of the past century and in the first two decades of the new century is largely due to the disruption of the relationship between the human body and its symbiotic microbiota, and not pathogens. The interaction of the human immune system with symbionts is not accompanied by inflammation, but is a physiological norm. This is achieved via microbiota control by the immune system through a complex balance of pro-inflammatory and suppressive responses, and only a disturbance of this balance can trigger pathophysiological mechanisms. This review discusses the establishment of homeostatic relationships during immune system development and intestinal bacterial colonization through the interaction of milk glycans, mucins, and secretory immunoglobulins. In particular, the role of fucose and fucosylated glycans in the mechanism of interactions between host epithelial and immune cells is discussed.
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