Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/ijms22084020
Keywords
diabetic retinopathy; antioxidants; oxidative stress; management; clinical practice; ophthalmology; retina; nutrition; nutraceuticals; multivitamin complex
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The review suggests that antioxidant supplementation in adult Type 1 and Type 2 diabetes mellitus patients without retinopathy or mild-to-moderate nonproliferative DR and without diabetic macular edema has a IIB level of recommendation as a complementary therapy with standard medical care.
Oxidative stress has been postulated as an underlying pathophysiologic mechanism of diabetic retinopathy (DR), the main cause of avoidable blindness in working-aged people. This review addressed the current daily clinical practice of DR and the role of antioxidants in this practice. A systematic review of the studies on antioxidant supplementation in DR patients was presented. Fifteen studies accomplished the inclusion criteria. The analysis of these studies concluded that antioxidant supplementation has a IIB level of recommendation in adult Type 1 and Type 2 diabetes mellitus subjects without retinopathy or mild-to-moderate nonproliferative DR without diabetic macular oedema as a complementary therapy together with standard medical care.
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