4.7 Article

Lasius fuliginosus Nest Carton as a Source of New Promising Bioactive Extracts with Chemopreventive Potential

Journal

Publisher

MDPI
DOI: 10.3390/ijms22094392

Keywords

jet black ants; carton derived extracts; biochemical analysis; FTIR spectra; antioxidative capacity; chemopreventive effect; anticancer effect; melanoma cells

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Six new water extracts obtained from nest carton of jet black ants were found to have significant antioxidative and anticancer effects. Extracts E1 and E2 showed the highest antioxidative potential, while extract E2 exhibited the most interesting chemopreventive activity against A-375 melanoma cells. The promising results of this study may lead to further research on the nest carton of jet black ant.
Six new water extracts (E1-E6) were obtained from nest carton produced by jet black ants Lasius fuliginosus and tested for their biochemical and bioactive properties, including antioxidative and anticancer effects. The present study demonstrated significant qualitative and quantitative differences in the content of individual biochemical constituents, as well as bioactive properties between the investigated samples. All tested extracts demonstrated antioxidant properties (determined using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS) methods), and the highest antioxidative potential was recorded in extracts E1 and E2 (188.96 and 313.67 mu g/mL of ascorbic acid equivalent for ABTS and 176.42 and 202.66 mu g/mL for DPPH reagent). Furthermore the six extracts exhibited strong inhibitory activity towards human melanoma cells of the A-375 CRL-1619 line in a dose-dependent manner. The most interesting chemopreventive activity was exhibited by extract E2, which inhibited the proliferation of A-375 cells to the greatest extent, while having a minimal effect on Vero cells. The effect on cancer cells has been confirmed using the Electric Cell-substrate Impedance Sensing (ECIS) technique. Significant impedance changes have been detected in A-375 and Vero cells following the administration of extract E2. The obtained results are really promising and constitute the basis for further research on the nest carton of jet black ant.

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