Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 10, Pages -Publisher
MDPI
DOI: 10.3390/ijms22105161
Keywords
anti-inflammation; YD1; peptide drug; NF-kappa B; RAW 264.7; TLR-4; MyD88; AKT
Funding
- Chosun University
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The novel antimicrobial peptide YD1 isolated from Kimchi exhibits strong anti-inflammatory effects by up-regulating the Nrf2 pathway and suppressing the NF-kappa B pathway, resulting in reduced proinflammatory cytokine production. YD1 also acts as a potent antioxidant by inhibiting NO and PGE(2) production, indicating its potential as a therapeutic agent.
In this study, we investigate the immunomodulatory effects of a novel antimicrobial peptide, YD1, isolated from Kimchi, in both in vitro and in vivo models. We establish that YD1 exerts its anti-inflammatory effects via up-regulation of the Nrf2 pathway, resulting in the production of HO-1, which suppresses activation of the NF-kappa B pathway, including the subsequent proinflammatory cytokines IL-1 beta, IL-6, and TNF-alpha. We also found that YD1 robustly suppresses nitric oxide (NO) and prostaglandin E2 (PGE(2)) production by down-regulating the expression of the upstream genes, iNOS and COX-2, acting as a strong antioxidant. Collectively, YD1 exhibits vigorous anti-inflammatory and antioxidant activity, presenting it as an interesting potential therapeutic agent.
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