Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 7, Pages -Publisher
MDPI
DOI: 10.3390/ijms22073591
Keywords
metastasis; epithelial-mesenchymal transition; transcription factor; Snail; Twist; ZEB
Funding
- National Research Foundation of Korea (NRF) - Korea government (MSIT) [2021R1A2C1011196, 2015R1A5A1008958]
- National Research Foundation of Korea [2021R1A2C1011196] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Epithelial-mesenchymal transition (EMT) plays a key role in both normal development and pathology, regulated by EMT-inducing transcription factors (EMT-TFs) to control the up- and down-regulation of specific proteins. This process is crucial for cancer metastasis.
Epithelial-mesenchymal transition (EMT) is generally observed in normal embryogenesis and wound healing. However, this process can occur in cancer cells and lead to metastasis. The contribution of EMT in both development and pathology has been studied widely. This transition requires the up- and down-regulation of specific proteins, both of which are regulated by EMT-inducing transcription factors (EMT-TFs), mainly represented by the families of Snail, Twist, and ZEB proteins. This review highlights the roles of key EMT-TFs and their post-translational regulation in cancer metastasis.
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