Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/ijms22083815
Keywords
non-small-cell lung cancer; EGFR; ALK; predictive biomarkers; liquid biopsies; next-generation sequencing
Funding
- PulmaGENE project - European Regional Development Fund (ERDF) through NORTE 2020 (Regional Operational Programme North 2014-2020) [NORTE-01-0247-FEDER033533]
- PulmaGENE project - European Regional Development Fund (ERDF) through LISBOA 2020 (Lisboa Operational Programme 2014-2020) [NORTE-01-0247-FEDER033533]
- BioISI project from the Science and Technology Foundation (FCT) of Portugal [UID/MULTI/04046/2021]
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Liquid biopsies are important for the early detection of gene alterations in NSCLC patients and disease management, highlighting the impact of NGS methods; however, their use in oncology is still limited.
Non-small-cell lung cancer (NSCLC) is a major cause of death worldwide. Alterations in such genes as EGFR and ALK are considered important biomarkers in NSCLC due to the existence of targeted therapies with specific tyrosine kinase inhibitors (TKIs). However, specific resistance-related mutations can occur during TKI treatment, which often result in therapy inefficacy. Liquid biopsies arise as a reliable tool for the early detection of these types of alterations, allowing a non-invasive follow-up of the patients. Furthermore, they can be essential for cancer screening, initial diagnosis and to check surgery success. Despite the great advantages of liquid biopsies in NSCLC and the high input that next-generation sequencing (NGS) approaches can provide in this field, its use in oncology is still limited. With improvement of assay sensitivity and the establishment of clinical guidelines for liquid biopsy analysis, it is expected that they will be used in routine procedures. This review focuses on the usefulness of liquid biopsies of NSCLC patients as a means to detect alterations in EGFR and ALK genes and in disease management, highlighting the impact of NGS methods.
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