Related references
Note: Only part of the references are listed.Tau (297-391) forms filaments that structurally mimic the core of paired helical filaments in Alzheimer's disease brain
Youssra K. Al-Hilaly et al.
FEBS LETTERS (2020)
A soluble truncated tau species related to cognitive dysfunction is elevated in the brain of cognitively impaired human individuals
Peng Liu et al.
SCIENTIFIC REPORTS (2020)
Truncation of Tau selectively facilitates its pathological activities
Jianlan Gu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2020)
Paired Helical Filament-Forming Region of Tau (297-391) Influences Endogenous Tau Protein and Accumulates in Acidic Compartments in Human Neuronal Cells
Saskia J. Pollack et al.
JOURNAL OF MOLECULAR BIOLOGY (2020)
Tau-induced upregulation of C/EBP beta-TRPC1-SOCE signaling aggravates tauopathies: A vicious cycle in Alzheimer neurodegeneration
Jinwang Ye et al.
AGING CELL (2020)
Early but not late conformational changes of tau in association with ubiquitination of neurofibrillary pathology in Alzheimer's disease brains
Vanessa J. Ibarra-Bracamontes et al.
BRAIN RESEARCH (2020)
Cleavage C-terminal to Asp leads to covalent crosslinking of long-lived human proteins
Zhen Wang et al.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2019)
The neuropathological diagnosis of Alzheimer's disease
Michael A. DeTure et al.
MOLECULAR NEURODEGENERATION (2019)
Spontaneous Isomerization of Long-Lived Proteins Provides a Molecular Mechanism for the Lysosomal Failure Observed in Alzheimer's Disease
Tyler R. Lambeth et al.
ACS CENTRAL SCIENCE (2019)
Mechanism of protein cleavage at asparagine leading to protein-protein cross-links
Michael G. Friedrich et al.
BIOCHEMICAL JOURNAL (2019)
Distribution of endogenous normal tau in the mouse brain
Atsuko Kubo et al.
JOURNAL OF COMPARATIVE NEUROLOGY (2019)
Tau Proteolysis in the Pathogenesis of Tauopathies: Neurotoxic Fragments and Novel Biomarkers
James P. Quinn et al.
JOURNAL OF ALZHEIMERS DISEASE (2018)
Tau Kinetics in Neurons and the Human Central Nervous System
Chihiro Sato et al.
NEURON (2018)
Relevance of Phosphorylation and Truncation of Tau to the Etiopathogenesis of Alzheimer's Disease
Yan Zhou et al.
FRONTIERS IN AGING NEUROSCIENCE (2018)
Precisely measured protein lifetimes in the mouse brain reveal differences across tissues and subcellular fractions
Eugenio F. Fornasiero et al.
NATURE COMMUNICATIONS (2018)
Calpain-mediated tau fragmentation is altered in Alzheimer's disease progression
Hsu-Hsin Chen et al.
SCIENTIFIC REPORTS (2018)
The Loss of - and -Tubulin Proteins Are a Pathological Hallmark of Chronic Alcohol Consumption and Natural Brain Ageing
Wajana L. Labisso et al.
BRAIN SCIENCES (2018)
Proteolytic Cleavage-Mechanisms, Function, and Omic Approaches for a Near-Ubiquitous Posttranslational Modification
Theo Klein et al.
CHEMICAL REVIEWS (2018)
A validated antibody panel for the characterization of tau post-translational modifications
Ebru Ercan et al.
MOLECULAR NEURODEGENERATION (2017)
Cryo-EM structures of tau filaments from Alzheimer's disease
Anthony W. P. Fitzpatrick et al.
NATURE (2017)
Whole Genome Expression Analysis in a Mouse Model of Tauopathy Identifies MECP2 as a Possible Regulator of Tau Pathology
Nicole M. Maphis et al.
FRONTIERS IN MOLECULAR NEUROSCIENCE (2017)
Spontaneous cleavage of proteins at serine and threonine is facilitated by zinc
Brian Lyons et al.
AGING CELL (2016)
Altered Proteins in the Aging Brain
Adila Elobeid et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2016)
Old Proteins in Man: A Field its Infancy
Roger J. W. Truscott et al.
TRENDS IN BIOCHEMICAL SCIENCES (2016)
Human prefrontal cortex phospholipids containing docosahexaenoic acid increase during normal adult aging, whereas those containing arachidonic acid decrease
Sarah E. Norris et al.
NEUROBIOLOGY OF AGING (2015)
Role of the Tau N-terminal region in microtubule stabilization revealed by new endogenous truncated forms
Maxime Derisbourg et al.
SCIENTIFIC REPORTS (2015)
Separate mechanisms for age-related truncation and racemisation of peptide-bound serine
Brian Lyons et al.
AMINO ACIDS (2014)
Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease
Zhentao Zhang et al.
NATURE MEDICINE (2014)
Age-dependent racemization of serine residues in a human chaperone protein
Michelle Y. S. Hooi et al.
PROTEIN SCIENCE (2013)
Dual modification of Alzheimer's disease PHF-tau protein by lysine methylation and ubiquitylation: a mass spectrometry approach
Stefani N. Thomas et al.
ACTA NEUROPATHOLOGICA (2012)
Molecular signatures of long-lived proteins: autolytic cleavage adjacent to serine residues
Shih-Ping Su et al.
AGING CELL (2012)
Degradation of an Old Human Protein AGE-DEPENDENT CLEAVAGE OF γS-CRYSTALLIN GENERATES A PEPTIDE THAT BINDS TO CELL MEMBRANES
Michael G. Friedrich et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Truncated tau and Aβ cooperatively impair mitochondria in primary neurons
Rodrigo A. Quintanilla et al.
NEUROBIOLOGY OF AGING (2012)
The ADNP Derived Peptide, NAP Modulates the Tubulin Pool: Implication for Neurotrophic and Neuroprotective Activities
Saar Oz et al.
PLOS ONE (2012)
Racemisation and human cataract. d-Ser, d-Asp/Asn and d-Thr are higher in the lifelong proteins of cataract lenses than in age-matched normal lenses
Michelle Yu Sung Hooi et al.
AGE (2011)
Tyrosine Nitration within the Pro line-Rich Region of Tau in Alzheimer's Disease
Juan F. Reyes et al.
AMERICAN JOURNAL OF PATHOLOGY (2011)
Amyloid-β and tau - a toxic pas de deux in Alzheimer's disease
Lars M. Ittner et al.
NATURE REVIEWS NEUROSCIENCE (2011)
Tau Truncation is a Productive Posttranslational Modification of Neurofibrillary Degeneration in Alzheimer's Disease
B. Kovacech et al.
CURRENT ALZHEIMER RESEARCH (2010)
A NH2 Tau Fragment Targets Neuronal Mitochondria at AD Synapses: Possible Implications for Neurodegeneration
Giuseppina Amadoro et al.
JOURNAL OF ALZHEIMERS DISEASE (2010)
β-Amyloid precursor protein and tau protein levels are differently regulated in human cerebellum compared to brain regions vulnerable to Alzheimer's type neurodegeneration
Mirsada Causevic et al.
NEUROSCIENCE LETTERS (2010)
Age-Dependent Deamidation of Lifelong Proteins in the Human Lens
Peter G. Hains et al.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2010)
Protein aging: Truncation of aquaporin 0 in human lens regions is a continuous age-dependent process
Anastasia Korlimbinis et al.
EXPERIMENTAL EYE RESEARCH (2009)
Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing
Yipeng Wang et al.
HUMAN MOLECULAR GENETICS (2009)
Human Truncated Tau is Using a Different Mechanism from Amyloid-beta to Damage the Blood-Brain Barrier
Andrej Kovac et al.
JOURNAL OF ALZHEIMERS DISEASE (2009)
In Vivo Turnover of Tau and APP Metabolites in the Brains of Wild-Type and Tg2576 Mice: Greater Stability of sAPP in the β-Amyloid Depositing Mice
Jose Morales-Corraliza et al.
PLOS ONE (2009)
Age-Related Changes in the Spatial Distribution of Human Lens α-Crystallin Products by MALDI Imaging Mass Spectrometry
Angus C. Grey et al.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2009)
β-amyloid burden is not associated with rates of brain atrophy
Keith A. Josephs et al.
ANNALS OF NEUROLOGY (2008)
Cleavage and conformational changes of tau protein follow phosphorylation during Alzheimer's disease
Siddhartha Mondragon-Rodriguez et al.
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY (2008)
Accumulation of aspartic Acid421- and glutamic Acid391-Cleaved tau in neurofibrillary tangles correlates with progression in Alzheimer disease
Gustavo Basurto-Islas et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2008)
Unfolding and aggregation of transthyretin by the truncation of 50 N-terminal amino acids
Mineyuki Mizuguchi et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2008)
Stepwise proteolysis liberates tau fragments that nucleate the Alzheimer-like aggregation of full-length tau in a neuronal cell model
Y. P. Wang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
The generation of a 17 kDa neurotoxic fragment:: An alternative mechanism by which tau mediates β-amyloid-induced neurodegeneration
SY Park et al.
JOURNAL OF NEUROSCIENCE (2005)
Molecular aging of tau:: disulfide-independent aggregation and non-enzymatic degradation in vitro and in vivo
A Watanabe et al.
JOURNAL OF NEUROCHEMISTRY (2004)
Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology
RA Rissman et al.
JOURNAL OF CLINICAL INVESTIGATION (2004)
Alzheimer's missing link?
[Anonymous]
MOLECULAR THERAPY (2003)
Caspase cleavage of tau: Linking amyloid and neurofibrillary tangles in Alzheimer's disease
TC Gamblin et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Isoaspartate formation and neurodegeneration in Alzheimer's disease
T Shimizu et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2000)
Share Paper
