Related references
Note: Only part of the references are listed.Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span
Paul D. Robbins et al.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 61, 2021 (2021)
Sex-Specific Associations Between Cardiac Workload, Peripheral Vascular Calcification, and Bone Mineral Density: The Gambian Bone and Muscle Aging Study
Ayse Zengin et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2021)
Inhibition of miR-29-3p isoforms via tough decoy suppresses osteoblast function in homeostasis but promotes intermittent parathyroid hormone-induced bone anabolism
Henry C. Hrdlicka et al.
BONE (2021)
MiRNA-483-5p is involved in the pathogenesis of osteoporosis by promoting osteoclast differentiation
Keqian Li et al.
MOLECULAR AND CELLULAR PROBES (2020)
Keratinocytes-derived exosomal miRNA regulates osteoclast differentiation in middle ear cholesteatoma
NingYue Gong et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)
LPS-induced premature osteocyte senescence: Implications in inflammatory alveolar bone loss and periodontal disease pathogenesis
Ruben Aquino-Martinez et al.
BONE (2020)
The senotherapeutic drug ABT-737 disrupts aberrant p21 expression to restore liver regeneration in adult mice
Birgit Ritschka et al.
GENES & DEVELOPMENT (2020)
Mitochondria-to-nucleus retrograde signaling drives formation of cytoplasmic chromatin and inflammation in senescence
Maria Grazia Vizioli et al.
GENES & DEVELOPMENT (2020)
Anti-Ageing Effect of Physalis alkekengi Ethyl Acetate Layer on a d-galactose-Induced Mouse Model through the Reduction of Cellular Senescence and Oxidative Stress
Kaiyue Sun et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
Targeted Reduction of Senescent Cell Burden Alleviates Focal Radiotherapy-Related Bone Loss
Abhishek Chandra et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2020)
Poly (ADP-ribose) polymerase 1 inhibition prevents neurodegeneration and promotes α-synuclein degradation via transcription factor EB-dependent autophagy in mutant α-synucleinA53T model of Parkinson's disease
Kanmin Mao et al.
AGING CELL (2020)
ATM is a key driver of NF-κB-dependent DNA-damage-induced senescence, stem cell dysfunction and aging
Jing Zhao et al.
AGING-US (2020)
Irradiation-induced senescence of bone marrow mesenchymal stem cells aggravates osteogenic differentiation dysfunction via paracrine signaling
Jiangtao Bai et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2020)
DNA Damage Response A Molecular Lynchpin in the Pathobiology of Arteriosclerotic Calcification
Melinda Duer et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2020)
Parathyroid hormone ameliorates temporomandibular joint osteoarthritic-like changes related to age
Chen Cui et al.
CELL PROLIFERATION (2020)
Inhibition of the epigenetic suppressor EZH2 primes osteogenic differentiation mediated by BMP2
Amel Dudakovic et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2020)
The CD153 vaccine is a senotherapeutic option for preventing the accumulation of senescent T cells in mice
Shota Yoshida et al.
NATURE COMMUNICATIONS (2020)
The Senolytic Drug Navitoclax (ABT-263) Causes Trabecular Bone Loss and Impaired Osteoprogenitor Function in Aged Mice
Anuj K. Sharma et al.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)
A single dose of zoledronate preserves bone mineral density for up to 2 years after a second course of romosozumab
M. R. McClung et al.
OSTEOPOROSIS INTERNATIONAL (2020)
Mitochondrial dysfunction impairs osteogenesis, increases osteoclast activity, and accelerates age related bone loss
Philip F. Dobson et al.
SCIENTIFIC REPORTS (2020)
Assessing the incidence of osteosarcoma among teriparatide users based on Medicare Part D andUSState Cancer Registry Data
Alicia Gilsenan et al.
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY (2020)
Senotherapeutic drugs for human intervertebral disc degeneration and low back pain
Hosni Cherif et al.
ELIFE (2020)
Osteoblast-Osteoclast Communication and Bone Homeostasis
Jung-Min Kim et al.
CELLS (2020)
Histone demethylase LSD1 is critical for endochondral ossification during bone fracture healing
Jun Sun et al.
SCIENCE ADVANCES (2020)
Independent Roles of Estrogen Deficiency and Cellular Senescence in the Pathogenesis of Osteoporosis: Evidence in Young Adult Mice and Older Humans
Joshua N. Farr et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2019)
Poly(ADP-ribose) polymerase 1 accelerates vascular calcification by upregulating Runx2
Cheng Wang et al.
NATURE COMMUNICATIONS (2019)
Reactive Oxygen Species in Osteoclast Differentiation and Possible Pharmaceutical Targets of ROS-Mediated Osteoclast Diseases
Taiwo Samuel Agidigbi et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)
Poly(ADP-Ribose) Links the DNA Damage Response and Biomineralization
Karin H. Mueller et al.
CELL REPORTS (2019)
MiRNA-19a-3p alleviates the progression of osteoporosis by targeting HDAC4 to promote the osteogenic differentiation of hMSCs
Rijiang Chen et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)
NAD plus consumption by PARP1 in response to DNA damage triggers metabolic shift critical for damaged cell survival
Michael M. Murata et al.
MOLECULAR BIOLOGY OF THE CELL (2019)
miR-219a-5p Regulates Rorβ During Osteoblast Differentiation and in Age-related Bone Loss
Ruben Aquino-Martinez et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2019)
MiRNA-199a-5p positively regulated RANKL-induced osteoclast differentiation by target Mafb protein
Kai Guo et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2019)
Elimination of senescent osteoclast progenitors has no effect on the age-associated loss of bone mass in mice
Ha-Neui Kim et al.
AGING CELL (2019)
Olaparib induced senescence under P16 or P53 dependent manner in ovarian cancer
Zehua Wang et al.
JOURNAL OF GYNECOLOGIC ONCOLOGY (2019)
A nutritional memory effect counteracts the benefits of dietary restriction in old mice
Oliver Hahn et al.
NATURE METABOLISM (2019)
Aspirin ameliorates the long-term adverse effects of doxorubicin through suppression of cellular senescence
Mingxiao Feng et al.
FASEB BIOADVANCES (2019)
Effects of physical activity on sclerostin concentrations
Malgorzata Janik et al.
ENDOKRYNOLOGIA POLSKA (2018)
Primary Osteoporosis Is Not Reflected by Disease-Specific DNA Methylation or Accelerated Epigenetic Age in Blood
Eduardo Fernandez-Rebollo et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2018)
MiRNA-133a is involved in the regulation of postmenopausal osteoporosis through promoting osteoclast differentiation
Zhongqi Li et al.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2018)
Defective autophagy in osteoblasts induces endoplasmic reticulum stress and causes remarkable bone loss
Huixia Li et al.
AUTOPHAGY (2018)
Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence
Luis Rajman et al.
CELL METABOLISM (2018)
Proteasome inhibitor bortezomib is a novel therapeutic agent for focal radiation-induced osteoporosis
Abhishek Chandra et al.
FASEB JOURNAL (2018)
Enhancer of zeste homolog 2 (Ezh2) controls bone formation and cell cycle progression during osteogenesis in mice
Amel Dudakovic et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2018)
Effects of 24 Months of Treatment With Romosozumab Followed by 12 Months of Denosumab or Placebo in Postmenopausal Women With Low Bone Mineral Density: A Randomized, Double-Blind, Phase 2, Parallel Group Study
Michael R. McClung et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2018)
The senescence-associated secretory phenotype is potentiated by feedforward regulatory mechanisms involving Zscan4 and TAK1
Boyi Zhang et al.
NATURE COMMUNICATIONS (2018)
Small-molecule MDM2 antagonists attenuate the senescence-associated secretory phenotype
Christopher D. Wiley et al.
SCIENTIFIC REPORTS (2018)
Bone-related Circulating MicroRNAs miR-29b-3p, miR-550a-3p, and miR-324-3p and their Association to Bone Microstructure and Histomorphometry
Xaver Feichtinger et al.
SCIENTIFIC REPORTS (2018)
Regulation of Breast Cancer-Induced Osteoclastogenesis by MacroH2A1.2 Involving EZH2-Mediated H3K27me3
Jinman Kim et al.
CELL REPORTS (2018)
Boosting ATM activity alleviates aging and extends lifespan in a mouse model of progeria
Minxian Qian et al.
ELIFE (2018)
Epigenetic enzymes influenced by oxidative stress and hypoxia mimetic in osteoblasts are differentially expressed in patients with osteoporosis and osteoarthritis
Peter Vrtacnik et al.
SCIENTIFIC REPORTS (2018)
PARP1 inhibitor (PJ34) improves the function of aging-induced endothelial progenitor cells by preserving intracellular NAD+ levels and increasing SIRT1 activity
Siyuan Zha et al.
STEM CELL RESEARCH & THERAPY (2018)
Fisetin is a senotherapeutic that extends health and lifespan
Matthew J. Yousefzadeh et al.
EBIOMEDICINE (2018)
Poly(ADP-ribose) drives pathologic α-synuclein neurodegeneration in Parkinson's disease
Tae-In Kam et al.
SCIENCE (2018)
Wnt1 is an Lrp5-independent bone-anabolic Wnt ligand
Julia Luther et al.
SCIENCE TRANSLATIONAL MEDICINE (2018)
The MacroH2A1.1-PARP1 Axis at the Intersection Between Stress Response and Metabolism
Sarah Hurtado-Bages et al.
FRONTIERS IN GENETICS (2018)
Histone demethylase LSD1 regulates bone mass by controlling WNT7B and BMP2 signaling in osteoblasts
Jun Sun et al.
BONE RESEARCH (2018)
Calcium-sensing receptor polymorphisms increase the risk of osteoporosis in ageing males
Andrea Di Nisio et al.
ENDOCRINE (2018)
Autophagy controls mesenchymal stem cell properties and senescence during bone aging
Yang Ma et al.
AGING CELL (2018)
mTOR pathway activation drives lung cell senescence and emphysema
Amal Houssaini et al.
JCI INSIGHT (2018)
Suppression of Sclerostin Alleviates Radiation-Induced Bone Loss by Protecting Bone-Forming Cells and Their Progenitors Through Distinct Mechanisms
Abhishek Chandra et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2017)
Sirtuin-3 Promotes Adipogenesis, Osteoclastogenesis, and Bone Loss in Aging Male Mice
Linh Ho et al.
ENDOCRINOLOGY (2017)
Distinct DNA methylation profiles in bone and blood of osteoporotic and healthy postmenopausal women
Sjur Reppe et al.
EPIGENETICS (2017)
PARPs and ADP-ribosylation: recent advances linking molecular functions to biological outcomes
Rebecca Gupte et al.
GENES & DEVELOPMENT (2017)
Epigenome-wide Association of DNA Methylation in Whole Blood With Bone Mineral Density
John A. Morris et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2017)
Romosozumab (sclerostin monoclonal antibody) versus teriparatide in postmenopausal women with osteoporosis transitioning from oral bisphosphonate therapy: a randomised, open-label, phase 3 trial
Bente L. Langdahl et al.
LANCET (2017)
Targeting cellular senescence prevents age-related bone loss in mice
Joshua N. Farr et al.
NATURE MEDICINE (2017)
Extracellular Matrices for Bone Regeneration: A Literature Review
Alaa Mansour et al.
TISSUE ENGINEERING PART A (2017)
Identification of HSP90 inhibitors as a novel class of senolytics
Heike Fuhrmann-Stroissnigg et al.
NATURE COMMUNICATIONS (2017)
Rapamycin treatment attenuates age-associated periodontitis in mice
Jonathan Y. An et al.
GEROSCIENCE (2017)
DNA damage and senescence in osteoprogenitors expressing Qsx1 may cause their decrease with age
Ha-Neui Kim et al.
AGING CELL (2017)
Rapamycin inhibits the secretory phenotype of senescent cells by a Nrf2-independent mechanism
Rong Wang et al.
AGING CELL (2017)
Oxidative stress in bone remodeling: role of antioxidants
Vladana Domazetovic et al.
CLINICAL CASES IN MINERAL AND BONE METABOLISM (2017)
New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463
Yi Zhu et al.
AGING-US (2017)
An overview and management of osteoporosis
Tumay Sozen et al.
EUROPEAN JOURNAL OF RHEUMATOLOGY (2017)
Mammalian Mitochondria and Aging: An Update
Timo E. S. Kauppila et al.
CELL METABOLISM (2017)
Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice
Jianhui Chang et al.
NATURE MEDICINE (2016)
Abrogation of Age-Induced MicroRNA-195 Rejuvenates the Senescent Mesenchymal Stem Cells by Reactivating Telomerase
Motoi Okada et al.
STEM CELLS (2016)
Zoledronate Attenuates Accumulation of DNA Damage in Mesenchymal Stem Cells and Protects Their Function
Juhi Misra et al.
STEM CELLS (2016)
miR-195 in human primary mesenchymal stromal/stem cells regulates proliferation, osteogenesis and paracrine effect on angiogenesis
Maria Ines Almeida et al.
ONCOTARGET (2016)
Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors
Yi Zhu et al.
AGING CELL (2016)
Discovery of piperlongumine as a potential novel lead for the development of senolytic agents
Yingying Wang et al.
AGING-US (2016)
Pathways of aging: comparative analysis of gene signatures in replicative senescence and stress induced premature senescence
Kamil C. Kural et al.
BMC GENOMICS (2016)
Direct effects of physical training on markers of bone metabolism and serum sclerostin concentrations in older adults with low bone mass
Gabriella Csaszarne Gombos et al.
BMC MUSCULOSKELETAL DISORDERS (2016)
Aging alters bone-fat reciprocity by shifting in vivo mesenchymal precursor cell fate towards an adipogenic lineage
Lakshman Singh et al.
BONE (2016)
DNA Hypomethylation and Histone Variant macroH2A1 Synergistically Attenuate Chemotherapy-Induced Senescence to Promote Hepatocellular Carcinoma Progression
Michela Borghesan et al.
CANCER RESEARCH (2016)
Oxidative Stress-Related Biomarkers in Postmenopausal Osteoporosis: A Systematic Review and Meta-Analyses
Qiaozhen Zhou et al.
DISEASE MARKERS (2016)
Enhancer of Zeste Homolog 2 Inhibition Stimulates Bone Formation and Mitigates Bone Loss Caused by Ovariectomy in Skeletally Mature Mice
Amel Dudakovic et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2016)
Identification of Senescent Cells in the Bone Microenvironment
Joshua N. Farr et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2016)
Circulating microRNA Signatures in Patients With Idiopathic and Postmenopausal Osteoporosis and Fragility Fractures
Roland Kocijan et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2016)
miRNA-29b improves bone healing in mouse fracture model
Wayne Y. Lee et al.
MOLECULAR AND CELLULAR ENDOCRINOLOGY (2016)
Autophagy maintains stemness by preventing senescence
Laura Garcia-Prat et al.
NATURE (2016)
Naturally occurring p16Ink4a-positive cells shorten healthy lifespan
Darren J. Baker et al.
NATURE (2016)
Nuclear DNA damage signalling to mitochondria in ageing
Evandro Fei Fang et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2016)
Carcinogenicity risk assessment of romosozumab: A review of scientific weight-of-evidence and findings in a rat lifetime pharmacology study
Luc Chouinard et al.
REGULATORY TOXICOLOGY AND PHARMACOLOGY (2016)
Histone H3K9 Acetyltransferase PCAF Is Essential for Osteogenic Differentiation Through Bone Morphogenetic Protein Signaling and May Be Involved in Osteoporosis
Ping Zhang et al.
STEM CELLS (2016)
Identification of Novel EZH2 Targets Regulating Osteogenic Differentiation in Mesenchymal Stem Cells
Sarah Hemming et al.
STEM CELLS AND DEVELOPMENT (2016)
miRNAs Related to Skeletal Diseases
Claudine Seeliger et al.
STEM CELLS AND DEVELOPMENT (2016)
MiR-148a the epigenetic regulator of bone homeostasis is increased in plasma of osteoporotic postmenopausal women
Ajda Bedene et al.
WIENER KLINISCHE WOCHENSCHRIFT (2016)
Loss of Rictor with aging in osteoblasts promotes age-related bone loss
Pinling Lai et al.
CELL DEATH & DISEASE (2016)
ARTD1 regulates osteoclastogenesis and bone homeostasis by dampening NF-κB-dependent transcription of IL-1β
Agnieszka Robaszkiewicz et al.
SCIENTIFIC REPORTS (2016)
The Achilles' heel of senescent cells: from transcriptome to senolytic drugs
Yi Zhu et al.
AGING CELL (2015)
Quantifying the osteocyte network in the human skeleton
Pascal R. Buenzli et al.
BONE (2015)
Methylation of Bone SOST, Its mRNA, and Serum Sclerostin Levels Correlate Strongly With Fracture Risk in Postmenopausal Women
Sjur Reppe et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2015)
Chromatin to Clinic: The Molecular Rationale for PARP1 Inhibitor Function
Felix Y. Feng et al.
MOLECULAR CELL (2015)
MacroH2A1 and ATM Play Opposing Roles in Paracrine Senescence and the Senescence-Associated Secretory Phenotype
Hongshan Chen et al.
MOLECULAR CELL (2015)
Global miRNA expression and correlation with mRNA levels in primary human bone cells
Navya Laxman et al.
RNA (2015)
Aging with ING: a comparative study of different forms of stress induced premature senescence
Uma Karthika Rajarajacholan et al.
ONCOTARGET (2015)
PTH1-34 Blocks Radiation-induced Osteoblast Apoptosis by Enhancing DNA Repair through Canonical Wnt Pathway
Abhishek Chandra et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
Effects of Age and Estrogen on Skeletal Gene Expression in Humans as Assessed by RNA Sequencing
Joshua N. Farr et al.
PLOS ONE (2015)
Dysregulation of SIRT-1 in aging mice increases skeletal muscle fatigue by a PARP-1-dependent mechanism
Junaith S. Mohamed et al.
AGING-US (2014)
Effects of age on bone mRNA levels of sclerostin and other genes relevant to bone metabolism in humans
Matthew M. Roforth et al.
BONE (2014)
Mouse models of telomere dysfunction phenocopy skeletal changes found in human age-related osteoporosis
Tracy A. Brennan et al.
DISEASE MODELS & MECHANISMS (2014)
The role of p38 signaling and poly(ADP-ribosyl)ation-induced metabolic collapse in the osteogenic differentiation-coupled cell death pathway
Agnieszka Robaszkiewicz et al.
FREE RADICAL BIOLOGY AND MEDICINE (2014)
Serum Levels of Sclerostin and Dickkopf-1: Effects of Age, Gender and Fracture Status
Peter Dovjak et al.
GERONTOLOGY (2014)
Sirtuin1 (Sirt1) Promotes Cortical Bone Formation by Preventing β-Catenin Sequestration by FoxO Transcription Factors in Osteoblast Progenitors
Srividhya Iyer et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Romosozumab in Postmenopausal Women with Low Bone Mineral Density
Michael R. McClung et al.
NEW ENGLAND JOURNAL OF MEDICINE (2014)
Poly(ADP-ribose) polymerase-dependent energy depletion occurs through inhibition of glycolysis
Shaida A. Andrabi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
ARTD1/PARP1 Negatively Regulates Glycolysis by Inhibiting Hexokinase 1 Independent of NAD+ Depletion
Elise Fouquerel et al.
CELL REPORTS (2014)
Hypoxia Enhances the Senescence Effect of Bortezomib-The Proteasome Inhibitor-On Human Skin Fibroblasts
Rafal Kretowski et al.
BIOMED RESEARCH INTERNATIONAL (2014)
PARP1 enhances inflammatory cytokine expression by alteration of promoter chromatin structure in microglia
Ricardo Ivan Martinez-Zamudio et al.
BRAIN AND BEHAVIOR (2014)
JAG1 and COL1A1 polymorphisms and haplotypes in relation to bone mineral density variations in postmenopausal Mexican-Mestizo Women
David Rojano-Mejia et al.
AGE (2013)
Genome-wide profiling of bone reveals differentially methylated regions in osteoporosis and osteoarthritis
Jesus Delgado-Calle et al.
ARTHRITIS AND RHEUMATISM (2013)
Serum sclerostin levels in healthy men over 50 years of age
Harjit Pal Bhattoa et al.
JOURNAL OF BONE AND MINERAL METABOLISM (2013)
DNA damage drives accelerated bone aging via an NF-κB-dependent mechanism
Qian Chen et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2013)
Sclerostin is expressed in osteoclasts from aged mice and reduces osteoclast-mediated stimulation of mineralization
Kuniaki Ota et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2013)
HDAC7 Inhibits Osteoclastogenesis by Reversing RANKL-Triggered β-Catenin Switch
Zixue Jin et al.
MOLECULAR ENDOCRINOLOGY (2013)
mTOR is a key modulator of ageing and age-related disease
Simon C. Johnson et al.
NATURE (2013)
The Polyphenol Fisetin Protects Bone by Repressing NF-κB and MKP-1-Dependent Signaling Pathways in Osteoclasts
Laurent Leotoing et al.
PLOS ONE (2013)
Hypomethylation of Alu Elements in Post-Menopausal Women with Osteoporosis
Pornrutsami Jintaridth et al.
PLOS ONE (2013)
P21-PARP-1 Pathway Is Involved in Cigarette Smoke-Induced Lung DNA Damage and Cellular Senescence
Hongwei Yao et al.
PLOS ONE (2013)
Glucocorticoids suppress selected components of the senescence-associated secretory phenotype
Remi-Martin Laberge et al.
AGING CELL (2012)
Increased transcript level of poly(ADP-ribose) polymerase (PARP-1) in human tricuspid compared with bicuspid aortic valves correlates with the stenosis severity
Edit Nagy et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2012)
Histone Demethylases KDM4B and KDM6B Promote Osteogenic Differentiation of Human MSCs
Ling Ye et al.
CELL STEM CELL (2012)
Fisetin Inhibits Osteoclast Differentiation via Downregulation of p38 and c-Fos-NFATc1 Signaling Pathways
Sik-Won Choi et al.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2012)
High Serum Sclerostin Predicts the Occurrence of Osteoporotic Fractures in Postmenopausal Women: The Center of Excellence for Osteoporosis Research Study
Mohammed-Salleh M. Ardawi et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2012)
miR-182 is a negative regulator of osteoblast proliferation, differentiation, and skeletogenesis through targeting FoxO1
Kyoung Min Kim et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2012)
Quiescent fibroblasts are protected from proteasome inhibition-mediated toxicity
Aster Legesse-Miller et al.
MOLECULAR BIOLOGY OF THE CELL (2012)
Matrix IGF-1 maintains bone mass by activation of mTOR in mesenchymal stem cells
Lingling Xian et al.
NATURE MEDICINE (2012)
Age-Associated Changes In Oxidative Stress and NAD+ Metabolism In Human Tissue
Hassina Massudi et al.
PLOS ONE (2012)
Senescence-associated intrinsic mechanisms of osteoblast dysfunctions
Moustapha Kassem et al.
AGING CELL (2011)
PARP-1 Inhibition Increases Mitochondrial Metabolism through SIRT1 Activation
Peter Bai et al.
CELL METABOLISM (2011)
Tumor Suppressor and Aging Biomarker p16INK4a Induces Cellular Senescence without the Associated Inflammatory Secretory Phenotype
Jean-Philippe Coppe et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Trabecular Bone Microstructure and Local Gene Expression in Iliac Crest Biopsies of Men With Idiopathic Osteoporosis
Janina M. Patsch et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2011)
Determinants of Serum Sclerostin in Healthy Pre- and Postmenopausal Women
Mohammed-Salleh M. Ardawi et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2011)
Relation of Age, Gender, and Bone Mass to Circulating Sclerostin Levels in Women and Men
Ulrike I. Moedder et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2011)
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
Darren J. Baker et al.
NATURE (2011)
Matrix-embedded cells control osteoclast formation
Jinhu Xiong et al.
NATURE MEDICINE (2011)
Evidence for osteocyte regulation of bone homeostasis through RANKL expression
Tomoki Nakashima et al.
NATURE MEDICINE (2011)
The human DEK oncogene regulates DNA damage response signaling and repair
Gina M. Kavanaugh et al.
NUCLEIC ACIDS RESEARCH (2011)
Calorie Restriction: Is AMPK a Key Sensor and Effector?
Carles Canto et al.
PHYSIOLOGY (2011)
Decreased oxidative stress and greater bone anabolism in the aged, when compared to the young, murine skeleton with parathyroid hormone administration
Robert L. Jilka et al.
AGING CELL (2010)
The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression
Jean -Philippe Coppe et al.
ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE (2010)
High-Affinity Interaction of Poly(ADP-ribose) and the Human DEK Oncoprotein Depends upon Chain Length
Joerg Fahrer et al.
BIOCHEMISTRY (2010)
From Estrogen-Centric to Aging and Oxidative Stress: A Revised Perspective of the Pathogenesis of Osteoporosis
Stavros C. Manolagas
ENDOCRINE REVIEWS (2010)
Inflammatory and age-related pathologies in mice with ectopic expression of human PARP-1
Aswin Mangerich et al.
MECHANISMS OF AGEING AND DEVELOPMENT (2010)
Parathyroid hormone suppresses osteoblast apoptosis by augmenting DNA repair
Matthew Schnoke et al.
BONE (2009)
Sclerostin Antibody Treatment Increases Bone Formation, Bone Mass, and Bone Strength in a Rat Model of Postmenopausal Osteoporosis
Xiaodong Li et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2009)
Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion
Francis Rodier et al.
NATURE CELL BIOLOGY (2009)
TGF-β1-induced migration of bone mesenchymal stem cells couples bone resorption with formation
Yi Tang et al.
NATURE MEDICINE (2009)
MOLECULAR ORIGINS OF CANCER DNA Damage, Aging, and Cancer
Jan H. J. Hoeijmakers
NEW ENGLAND JOURNAL OF MEDICINE (2009)
Defects in telomere maintenance molecules impair osteoblast differentiation and promote osteoporosis
Robert J. Pignolo et al.
AGING CELL (2008)
Partial proteasome inhibition in human fibroblasts triggers accelerated M1 senescence or M2 crisis depending on p53 and Rb status
Niki Chondrogianni et al.
AGING CELL (2008)
Shared principles in NF-κB signaling
Matthew S. Hayden et al.
CELL (2008)
The roles of poly(ADP-ribose)-metabolizing enzymes in alkylation-induced cell death
O. Cohausz et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2008)
Effect of zinc on cellular poly(ADP-ribosyl)ation capacity
Andrea Kunzmann et al.
EXPERIMENTAL GERONTOLOGY (2008)
Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength
Xiaodong Li et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2008)
Effects of ubiquitin-proteasome system deregulation on the vascular senescence and atherosclerosis process in elderly patients
Raffaele Marfella et al.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2008)
Rapid regulation of telomere length is mediated by poly(ADP-ribose) polymerase-1
Sascha Beneke et al.
NUCLEIC ACIDS RESEARCH (2008)
Mutations in the telomerase component NHP2 cause the premature ageing syndrome dyskeratosis congenita
Tom Vulliamy et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Total oxidative/anti-oxidative status and relation to bone mineral density in osteoporosis
Ozlem Altindag et al.
RHEUMATOLOGY INTERNATIONAL (2008)
Mechanism of action, pharmacokinetic and pharmacodynamic profile, and clinical applications of nitrogen-containing bisphosphonates
D. B. Kimmel
JOURNAL OF DENTAL RESEARCH (2007)
Deletion of the developmentallv essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss
Yaroslava Ruzankina et al.
CELL STEM CELL (2007)
Oxidative DNA damage repair and parp 1 and parp 2 expression in Epstein-Barr virus-immortalized B lymphocyte cells from young subjects, old subjects, and centenarians
Marta Chevanne et al.
REJUVENATION RESEARCH (2007)
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
Wen Xue et al.
NATURE (2007)
COL1A1, ESR1, VDR and TGFB1 polymorphisms and haplotypes in relation to BMD in Spanish postmenopausal women
M. Bustamante et al.
OSTEOPOROSIS INTERNATIONAL (2007)
DNA repair and PARP in aging
Alexander Buerkle
FREE RADICAL RESEARCH (2006)
Werner Syndrome and Mutations of the WRN and LMNA Genes in France
Nancy A. Uhrhammer et al.
HUMAN MUTATION (2006)
Inhibition of osteoblast differentiation but not adipocyte differentiation of mesenchymal stem cells by sera obtained from aged females
Basem M. Abdallah et al.
BONE (2006)
Atm-deficient mice: an osteoporosis model with defective osteoblast differentiation and increased osteoclastogenesis
Naslin Rasheed et al.
HUMAN MOLECULAR GENETICS (2006)
PARP1 is a TRF2-associated poly(ADP-ribose)polymerase and protects eroded telomere
M Gomez et al.
MOLECULAR BIOLOGY OF THE CELL (2006)
Histone deacetylase inhibitors promote osteoblast maturation
TM Schroeder et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2005)
Aspirin reduces endothelial cell senescence
SM Bode-Böger et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)
The human Rap1 protein complex and modulation of telomere length
MS O'Connor et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Bone neoplasms in F344 rats given teriparatide [rhPTH(1-34)] are dependent on duration of treatment and dose
JL Vahle et al.
TOXICOLOGIC PATHOLOGY (2004)
Study of telomere length reveals rapid aging of human marrow stromal cells following in vitro expansion
MA Baxter et al.
STEM CELLS (2004)
A DNA damage checkpoint response in telomere-initiated senescence
FD di Fagagna et al.
NATURE (2003)
Biology of the basic multicellular unit and the pathophysiology of osteoporosis
RL Jilka
MEDICAL AND PEDIATRIC ONCOLOGY (2003)
Recombinant human PTH 1-34 (Forteo): An anabolic drug for osteoporosis
C Deal et al.
CLEVELAND CLINIC JOURNAL OF MEDICINE (2003)
Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence
M Narita et al.
CELL (2003)
Osteoclast differentiation and activation
WJ Boyle et al.
NATURE (2003)
The functional role of poly(ADP-ribose)polymerase 1 as novel coactivator of NF-κB in inflammatory disorders
PO Hassa et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2002)
Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor
SW Yu et al.
SCIENCE (2002)
Premature aging in mice deficient in DNA repair and transcription
J de Boer et al.
SCIENCE (2002)
Effect of growth factors on nuclear and mitochondrial ADP-ribosylation processes during astroglial cell development and aging in culture
VS Purrello et al.
MECHANISMS OF AGEING AND DEVELOPMENT (2002)
Cellular senescence: a mechanism in the development of osteoporosis?
A Battmann et al.
ORTHOPADE (2001)
Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)
W Balemans et al.
HUMAN MOLECULAR GENETICS (2001)
Decline in osteocyte lacunar density in human cortical bone is associated with accumulation of microcracks with age
D Vashishth et al.
BONE (2000)
RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism
J Li et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)