Journal
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
Volume 234, Issue -, Pages -Publisher
ELSEVIER GMBH
DOI: 10.1016/j.ijheh.2021.113722
Keywords
Human biomonitoring; Phthalates; HBM4EU; Human biomonitoring guidance values (HBM-GV); Risk assessment; Chemical policy
Funding
- European Union [733032]
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The widespread internal exposure of the European population to plasticizers has sparked the urgent need for toxicological interpretation. The European Human Biomonitoring Initiative (HBM4EU) has significantly contributed to understanding actual exposure levels and their impact on health. Human biomonitoring guidance values (HBM-GVs) have been derived for various phthalates and a non-phthalate substitute, aiding in health risk assessment.
Ubiquitous use of plasticizers has led to a widespread internal exposure of the European population. Until today, metabolites are detected in almost every urine sample analysed. This raised the urgent need for a toxicological interpretation of the internal exposure levels. The European Human Biomonitoring Initiative (HBM4EU) contributes substantially to the knowledge on the actual exposure of European citizens to chemicals prioritised within HBM4EU, on their potential impact on health and on the interpretation of these data to improve policy making. On that account, human biomonitoring guidance values (HBM-GVs) are derived for the general population and the occupationally exposed population agreed at HBM4EU consortium level. These values can be used to assess phthalate exposure levels measured in HBM studies in a health risk assessment context. HBM-GVs were derived for five phthalates (DEHP, DnBP, DiBP, BBzP and DPHP) and for the non-phthalate substitute Hexamoll? DINCH. For the adult general population, the HBM-GVs for the specific metabolite(s) of the respective parent compounds in urine are the following: 0.5 mg/L for the sum of 5-oxo-MEHP and 5-OH-MEHP; 0.19 mg/L for MnBP, 0.23 mg/L for MiBP; 3 mg/L for MBzP; 0.5 mg/L for the sum of oxo-MPHP and OH-MPHP and 4.5 mg/L for the sum of OH-MINCH and cx-MINCH. The present paper further specifies HBM-GVs for children and for workers.
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