4.5 Article

Dietary isoflavones intake is inversely associated with non-alcoholic fatty liver disease, hyperlipidaemia and hypertension

Journal

Publisher

TAYLOR & FRANCIS LTD
DOI: 10.1080/09637486.2021.1910630

Keywords

Isoflavones; hypertension; hyperlipidaemia; NAFLD; public health data

Funding

  1. National Natural Science Fund of China [81872616, 81573133]

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Total isoflavones, daidzein, and genistein intake were found to be inversely associated with NAFLD, hyperlipidaemia, and hypertension. Glycitein was inversely associated with hyperlipidaemia and hypertension.
This study investigated associations between total isoflavones and their categories (daidzein, genistein, glycitein) intake and the risks for metabolic disorders. We used the data of 6786 Chinese adults from the Nutrition Health Atlas Project. We performed multiple logistic regression and restricted cubic spline models assessing the risks for metabolic disorders (non-alcoholic fatty liver disease (NAFLD), hyperlipidaemia, hypertension, diabetes and overweight/obesity) in each category of isoflavones. Higher total isoflavones, daidzein and genistein intake were inversely associated with NAFLD (p < .05). Higher total isoflavones, daidzein, genistein and glycitein intake were also inversely associated with hyperlipidaemia (p < .01) and hypertension (p < .01). Dose-response analyses revealed that total isoflavones, daidzein, genistein and glycitein intakes were associated with the risks of metabolic disorders in a nonlinear trend. In conclusion, total isoflavones, daidzein and genistein intake were inversely associated with NAFLD, hyperlipidaemia and hypertension. Glycitein was inversely associated with hyperlipidaemia and hypertension.

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