Lectins purified from medicinal and edible mushrooms: Insights into their antiviral activity against pathogenic viruses

For thousands of years, fungi have been a valuable and promising source of therapeutic agents for treatment of various diseases. Mushroom is a macrofungus which has been cultivated worldwide for its nutritional value and medicinal applications. Several bioactive molecules were extracted from mushroom such as polysaccharides, lectins and terpenoids. Lectins are carbohydrate-binding proteins with non-immunologic origin. Lectins were classified according to their structure, origin and sugar specificity. This protein has different binding specificity with surface glycan moiety which determines its activity and therapeutic applications. A wide range of medicinal activities such as antitumor, antiviral, antimicrobial, immunomodulatory and antidiabetic were reported from sugar-binding proteins. However, glycan-binding protein from mushroom is not well explored as antiviral agent. The discovery of novel antiviral agents is a public health emergency to overcome the current pandemic and be ready for the upcoming viral pandemics. The mechanism of action of lectin against viruses targets numer-ous steps in viral life cycle such as viral attachment, entry and replication. This review described the history, clas-sification, purification techniques, structure-function relationship and different therapeutic applications of mushroom lectin. In addition, we focus on the antiviral activity, purification and physicochemical characteristics of some mushroom lectins. (c) 2021 Elsevier B.V. All rights reserved.

Automated summary

Fungi, especially mushrooms, have been a valuable source of bioactive molecules such as lectins with various therapeutic applications. Lectins can recognize glycan moieties, exhibiting a wide range of medicinal activities including antitumor, antiviral, antimicrobial, immunomodulatory, and antidiabetic effects.