Journal
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
Volume 58, Issue 1, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.ijantimicag.2021.106353
Keywords
Vancomycin-resistant Enterococcus faecium; Eravacycline; Tedizolid; Omadacycline; Lipoglycopeptides
Funding
- Taiwan Centers for Disease Control and Prevention, Ministry of Health and Welfare, Executive Yuan, Taiwan [MOHW106-CDC-C-114-114701]
- Taiwan Centers for Disease Control and Prevention, Minister of Health and Welfare, Executive Yuan, Taiwan [MOHW108-CDCC-114-134504]
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Multicenter surveillance of antimicrobial susceptibility was conducted for 235 vancomycin-resistant Enterococcus faecium (VREfm) isolates from 18 Taiwanese hospitals. The study found very low susceptibility rates to teicoplanin, dalbavancin, and telavancin, while tigecycline and eravacycline showed high activity against VREfm isolates in Taiwan. The susceptibility rates of VREfm isolates to oxazolidinone-class antibiotics were much lower compared to other parts of the world.
Multicenter surveillance of antimicrobial susceptibility was performed for 235 vancomycin-resistant En-terococcus faecium (VREfm) isolates from 18 Taiwanese hospitals. The minimum inhibitory concentrations (MICs) of eravacycline, omadacycline, lipoglycopeptides, and other comparator antibiotics were deter-mined using the broth microdilution method. Nearly all isolates of VREfm were not susceptible to te-icoplanin, dalbavancin, and telavancin, with susceptibility rates of 0.5%, 1.7% and 0.5%, respectively. Tige-cycline and eravacycline were active against 93.2% and 89.7% of the VREfm isolates, respectively. More -over, the susceptibility rates of quinupristin/dalfopristin, tedizolid, and linezolid were 59.1%, 84.2%, and 77.4%, respectively. Additionally, 94% of the VREfm isolates were classified as susceptible to daptomycin, and the MICs of omadacycline required to inhibit VREfm growth by 50% and 90% were 0.12 and 0.5 mg/L, respectively. Susceptibility rates of VREfm isolates to synthetic tetracyclines and daptomycin were slightly lower and to oxazolidinone-class antibiotics were much lower in Taiwan than those in other parts of the world. Continuous monitoring of VREfm resistance to novel antibiotics, including synthetic tetracyclines, oxazolidinone-class antibiotics, and daptomycin, is needed in Taiwan. (c) 2021 Elsevier Ltd and International Society of Antimicrobial Chemotherapy. All rights reserved.
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