4.7 Review

Leflunomide an immunomodulator with antineoplastic and antiviral potentials but drug-induced liver injury: A comprehensive review

Related references

Note: Only part of the references are listed.
Article Clinical Neurology

COVID-19 in teriflunomide-treated patients with multiple sclerosis

Amir Hadi Maghzi et al.

JOURNAL OF NEUROLOGY (2020)

Article Medicine, Research & Experimental

Leflunomide-induced liver injury in mice: Involvement of TLR4 mediated activation of PI3K/mTOR/NFκB pathway

Rabie E. Elshaer et al.

LIFE SCIENCES (2019)

Article Chemistry, Medicinal

Dihydroorotate dehydrogenase inhibitors in anti-infective drug research

Donatella Boschi et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)

Review Rheumatology

Cyclophosphamide-induced severe acute hepatitis in a rheumatic disease: case-based review

Dondu Uskudar Cansu et al.

RHEUMATOLOGY INTERNATIONAL (2019)

Article Biochemistry & Molecular Biology

Leflunomide: A promising drug with good antitumor potential

Chunying Zhang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

Article Virology

Antiviral activity of A771726, the active metabolite of leflunomide, against Junin virus

Claudia S. Sepulveda et al.

JOURNAL OF MEDICAL VIROLOGY (2018)

Article Pharmacology & Pharmacy

Mitochondrial dysfunction induced by leflunomide and its active metabolite

Jiekun Xuan et al.

TOXICOLOGY (2018)

Article Immunology

Teriflunomide and monomethylfumarate target HIV-induced neuroinflammation and neurotoxicity

Bjoern Ambrosius et al.

JOURNAL OF NEUROINFLAMMATION (2017)

Article Clinical Neurology

A case of lymphoma in a patient on teriflunomide treatment for relapsing multiple sclerosis

Anne Landais et al.

MULTIPLE SCLEROSIS AND RELATED DISORDERS (2017)

Review Pharmacology & Pharmacy

Antiviral treatment of BK virus viremia after kidney transplantation

Andrew D. Santeusanio et al.

AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY (2017)

Review Integrative & Complementary Medicine

Assessment of the Therapeutic Effect of Total Glucosides of Peony for Juvenile Idiopathic Arthritis: A Systematic Review and Meta-Analysis

Yongsong Cai et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2016)

Article Chemistry, Medicinal

Detection of in Vitro Metabolite Formation of Leflunomide: A Fluorescence Dynamics and Electronic Structure Study

Poornima Sharma et al.

JOURNAL OF MEDICINAL CHEMISTRY (2016)

Article Public, Environmental & Occupational Health

Effect of Rheum palmatum L. on NF- κ B signaling pathway of mice with acute liver failure

Rong-Zhen Zhang et al.

ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE (2015)

Article Endocrinology & Metabolism

1,25(OH)2D3 downregulates the Toll-like receptor 4-mediated inflammatory pathway and ameliorates liver injury in diabetic rats

H. Wang et al.

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION (2015)

Article

Evaluation of mechanism of hepatotoxicity of leflunomide using albino wistar rats

Lal Lodhi

African Journal of Pharmacy and Pharmacology (2014)

Review Neurosciences

Teriflunomide (Aubagio®) for the treatment of multiple sclerosis

Amit Bar-Or

EXPERIMENTAL NEUROLOGY (2014)

Article Surgery

Leflunomide suppresses growth in human medullary thyroid cancer cells

Amal Alhefdhi et al.

JOURNAL OF SURGICAL RESEARCH (2013)

Article Rheumatology

Therapeutic effect of leflunomide on the development of experimental lupus nephritis in mice

Chunyan He et al.

RHEUMATOLOGY INTERNATIONAL (2012)

Review Immunology

Leflunomide for cytomegalovirus: bench to bedside

B. Chacko et al.

TRANSPLANT INFECTIOUS DISEASE (2012)

Article Gastroenterology & Hepatology

Meta-analysis of combined therapy for adult hepatitis B virus-associated glomerulonephritis

Xiao-Yong Zheng et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2012)

Review Immunology

Akt and mTOR in B cell activation and differentiation

Jose J. Limon et al.

FRONTIERS IN IMMUNOLOGY (2012)

Article

Risk of hepatotoxicity with add-on leflunomide in rheumatoid arthritis patients

Rachna Gupta et al.

ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH (2011)

Article Pharmacology & Pharmacy

Neuroprotective, immunosuppressant and antineoplastic properties of mTOR inhibitors: current and emerging therapeutic options

Giuseppe Pignataro et al.

CURRENT OPINION IN PHARMACOLOGY (2011)

Article Pharmacology & Pharmacy

Inhibiting effects of Leflunomide metabolite on overexpression of CD147, MMP-2 and MMP-9 in PMA differentiated THP-1 cells

Jian-lin Huang et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2011)

Review Rheumatology

Hepatotoxicity related to antirheumatic drugs

Guruprasad P. Aithal

NATURE REVIEWS RHEUMATOLOGY (2011)

Article

Toxicidade hepática é rara em pacientes com artrite reumatoide usando terapia combinada de leflunomida e metotrexato

Jorge Augusto Nunes Rodrigues Alves et al.

Revista Brasileira De Reumatologia (2011)

Article Multidisciplinary Sciences

The Anti-Inflammatory Drug Leflunomide Is an Agonist of the Aryl Hydrocarbon Receptor

Edmond F. O'Donnell et al.

PLOS ONE (2010)

Editorial Material Gastroenterology & Hepatology

Drug-induced liver injury: Is it somehow foreseeable?

Giovanni Tarantino et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2009)

Article Pharmacology & Pharmacy

Genetic polymorphism of CYP1A2 and the toxicity of leflunomide treatment in rheumatoid arthritis patients

Petra Bohanec Grabar et al.

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY (2008)

Article Immunology

Leflunomide inhibits PDK1/Akt pathway and induces apoptosis of human mast cells

Norifumi Sawamukai et al.

JOURNAL OF IMMUNOLOGY (2007)

Review Infectious Diseases

Antivirals for the treatment of polyomavirus BK replication

Christine Hanssen Rinaldo et al.

EXPERT REVIEW OF ANTI-INFECTIVE THERAPY (2007)

Article Immunology

Polyomavirus-associated nephropathy: update on antiviral strategies

M. A. Josephson et al.

TRANSPLANT INFECTIOUS DISEASE (2006)

Article Surgery

Concurrent antiviral and immunosuppressive activities of leflunomide in vivo

AS Chong et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2006)

Article Rheumatology

Ankylosing spondylitis and symptom-modifying vs disease-modifying therapy

Nurullah Akkoc et al.

BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY (2006)

Review Biotechnology & Applied Microbiology

Idiosyncratic drug hepatotoxicity

N Kaplowitz

NATURE REVIEWS DRUG DISCOVERY (2005)

Article Cardiac & Cardiovascular Systems

Post-coronary artery bypass graft liver failure: A possible association with leflunomide

SC Thomasset et al.

ANNALS OF THORACIC SURGERY (2005)

Article Immunology

Mast cells and autoimmunity

M Rottem et al.

AUTOIMMUNITY REVIEWS (2005)

Review Rheumatology

Mast cells in inflammatory arthritis

PA Nigrovic et al.

ARTHRITIS RESEARCH & THERAPY (2005)

Review Pharmacology & Pharmacy

Leflunomide in the treatment of rheumatoid arthritis

EK Li et al.

CLINICAL THERAPEUTICS (2004)

Article Public, Environmental & Occupational Health

Leflunomide for the treatment of rheumatoid arthritis in clinical practice - Incidence and severity of hepatotoxicity

EN van Roon et al.

DRUG SAFETY (2004)

Article Gastroenterology & Hepatology

Leflunomide-induced acute hepatitis

C Sevilla-Mantilla et al.

DIGESTIVE AND LIVER DISEASE (2004)

Article Gastroenterology & Hepatology

Effect of leflunomide on immunological liver injury in mice

HW Yao et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2003)

Letter Medicine, General & Internal

Fatal hepatitis with leflunomide and itraconazole

A Legras et al.

AMERICAN JOURNAL OF MEDICINE (2002)

Review Rheumatology

Leflunomide: mode of action in the treatment of rheumatoid arthritis

FC Breedveld et al.

ANNALS OF THE RHEUMATIC DISEASES (2000)