Journal
INTERNAL AND EMERGENCY MEDICINE
Volume 16, Issue 8, Pages 2231-2241Publisher
SPRINGER-VERLAG ITALIA SRL
DOI: 10.1007/s11739-021-02749-1
Keywords
Antibiotics; Resistance; Novel; Multidrug-resistant
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Antimicrobial resistance poses a growing threat to public health, making it increasingly important for acute care physicians to be familiar with novel antibiotics for appropriate utilization in combating infections caused by resistant gram-negative bacteria in the acute care setting.
Antimicrobial resistance is a growing threat to public health and an increasingly common problem for acute care physicians to confront. Several novel antibiotics have been approved in the past decade to combat these infections; however, physicians may be unfamiliar with how to appropriately utilize them. The purpose of this review is to evaluate novel antibiotics active against resistant gram-negative bacteria and highlight clinical information regarding their use in the acute care setting. This review focuses on novel antibiotics useful in the treatment of infections caused by resistant gram-negative organisms that may be seen in the acute care setting. These novel antibiotics include ceftolozane/tazobactam, ceftazidime/avibactam, meropenem/vaborbactam, imipenem/cilistatin/relebactam, cefiderocol, plazomicin, eravacycline, and omadacycline. Acute care physicians should be familiar with these novel antibiotics so they can utilize them appropriately.
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