Journal
INDIAN JOURNAL OF SURGERY
Volume 84, Issue 1, Pages 21-27Publisher
SPRINGER INDIA
DOI: 10.1007/s12262-021-02809-y
Keywords
Malignant peritoneal mesothelioma; Hyperthermic intraperitoneal chemotherapy; Cytoreductive surgery
Categories
Ask authors/readers for more resources
Malignant mesotheliomas commonly occur in the pleural and peritoneal cavities, with symptoms such as ascites and abdominal pain. CRS-HIPEC treatment is more suitable for patients with good general condition, epithelioid histology, and other specific characteristics.
Malignant mesotheliomas develop commonly in the pleural cavity and second mesotheliomas arise in the peritoneal cavity (20-30%). Most frequent symptoms/signs are ascites (77%) and abdominal pain (f69%). Biopsy in these patients should be taken from the peritoneum by invasive method (laparotomy, laparoscopy and core needle biopsy). The couplet of systemic pemetrexed and cisplatin had an overall response rate of approximately 25% and a median overall survival of approximately 1 year. Patients with a good general condition, epithelioid histology, nonabdominal disease, complete or near cytoreduction (CC0/CC1), low Ki67 proliferative index and peritoneal cancer index (PCI) score less than 17 should be administered through cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) rather than palliative systemic chemotherapy. The survival rate with Ki67 <= 9% is higher than patients with Ki67 > 9. The basic principles of the CRS are not different from other peritoneal carcinomas. The combination of cisplatin and doxorubicin is the best recommended drug regimen for the hyperthermic intraperitoneal chemotherapy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available