Journal
IMMUNITY
Volume 54, Issue 4, Pages 603-605Publisher
CELL PRESS
DOI: 10.1016/j.immuni.2021.03.017
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A recent study identified an innate-like cytosolic DNA-sensing mechanism in aged CD4(+) T cells, driven by the KU complex, which exacerbates aging-related autoimmunity.
Adaptive immune cells are usually not equipped with pattern recognition receptors. In this issue of Immunity, Wang et al. revealed an innate-like'' cytosolic DNA-sensing mechanism by the KU complex in aged CD4(+) T cells, which exacerbates aging-related autoimmunity.
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