Astrocytes have a license to kill inflammatory T cells

Microbiome-induced interferon signaling through gut-derived natural killer cells is integral to minimize peripheral inflammatory responses in the brain and spinal cord. In a recent issue of Nature, Sanmarco, Wheeler, et al. define how interferon signaling induces LAMP1(+)TRAIL(+) astrocytes, which cause death of inflammatory T cells, mitigating degeneration in a mouse model of demyealination.

Automated summary

This study highlights the importance of microbiome-induced interferon signaling through gut-derived natural killer cells in minimizing inflammatory responses in the brain and spinal cord. The researchers showed that interferon signaling induces LAMP1(+)TRAIL(+) astrocytes, leading to the death of inflammatory T cells and mitigating degeneration in a mouse model of demyealination.