Journal
BRAIN RESEARCH
Volume 1622, Issue -, Pages 163-173Publisher
ELSEVIER
DOI: 10.1016/j.brainres.2015.06.020
Keywords
Endoplasmic reticulum stress; Vasogenic edema; Status epilepticus; eNOS; GRP78; SMI-71
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Funding
- National Research Foundation of Korea (NRF) Grant (MEST) [2013R1A6 A3A04058272]
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The blood-brain barrier (BBB) maintains the unique brain microenvironment, which is separated from the systemic circulating system. Since the endoplasmic reticulum (ER) is an important cell organelle that is responsible for protein synthesis, the correct folding and sorting of proteins contributing to cell survivals, ER stress is a potential cause of cell damage in various diseases. Therefore, it would be worthy to explore the the relationship between the ER stress and BBB disruption during vasogenic edema formation induced by epileptogenic insults. In the present study, we investigated the roles of ER stress in vasogenic edema and its related events in rat epilepsy models provoked by pilocarpine-induced status epilepticus (SE). SE-induced eNOS activation induces BBB breakdown via up-regulation of GRP78 expression and dysfunction of SMI-71 (an endothelial BBB marker) in the piriform cortex (PC). In addition, caveolin-1 peptide (an eNOS inhibitor) effectively attenuated GRP78 expression and down-regulation of SMI-71. Taken together, our findings suggest that eNOS-mediated ER stress may participate in SE-induced vasogenic edema formation. Therefore, the modulation of ER stress may be a considerable strategy for therapy in impairments of endothelial cell function. (C) 2015 Elsevier B.V. All rights reserved.
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