Journal
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
Volume 43, Issue 9, Pages 2644-2654Publisher
WILEY
DOI: 10.1002/hed.26730
Keywords
parapharyngeal space; parotid carcinoma; recurrence; surgical margin; survival
Categories
Funding
- NCI grant [P30 CA008748]
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The impact of parapharyngeal extension on margin status, local recurrence-free probability, and disease-specific survival in the resection of parotid carcinomas was evaluated. Results showed that parapharyngeal extension did not worsen oncologic outcomes, including margin positivity, local recurrence, and disease-specific survival.
Background Resection of parotid carcinomas involving the parapharyngeal space is challenging. How this affects tumor margin control, recurrence, and survival is unclear. Methods Patients who underwent resection of parotid carcinomas between 1985 and 2015 at Memorial Sloan Kettering Cancer Center were evaluated for the impact of parapharyngeal extension (PPE) on margin status, local recurrence-free probability (LRFP), and disease-specific survival (DSS). Results Out of 214 patients in whom preoperative imaging was available for review, 22 (10.3%) had PPE. Matched by histotypes, carcinomas with PPE had comparable margin positivity (p = 0.479), T classification (p = 0.316), pathologic risk (p = 0.936), and adjuvant therapy (p = 0.617) to those without PPE. The 3-year LRFP was 88.9% versus 95.4% (hazard ratio [HR] 2.23 after adjusting for pT classification, p = 0.342) and the 5-year DSS was 74.2% versus 69.5% (adjusted HR 0.45, p = 0.232) in patients with and without PPE. Conclusion PPE does not appear to worsen oncologic outcomes in the resection of parotid carcinomas.
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